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E1657

EHT 1864

Name: EHT 1864
Brand: SIGMA

≥98% (HPLC), Rac function inhibitor, powder

Sinónimos:

5-(5-(7-(Trifluoromethyl)quinolin-4-ylthio)pentyloxy)-2-(morpholinomethyl)-4H-pyran-4-one dihydrochloride

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Fórmula empírica (notación de Hill):

C₂₅H₂₇F₃N₂O₄S · 2HCl

Número CAS:

754240-09-0

Peso molecular:

581.47

UNSPSC Code:

12352200

PubChem Substance ID:

329799014

NACRES:

NA.77

MDL number:

MFCD11114384

Assay:

≥98% (HPLC)

Form:

powder

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Propiedades

Nombre del producto

EHT 1864, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H₂O: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

Cl.Cl.FC(F)(F)c1ccc2c(SCCCCCOC3=COC(CN4CCOCC4)=CC3=O)ccnc2c1

InChI

1S/C25H27F3N2O4S.2ClH/c26-25(27,28)18-4-5-20-21(14-18)29-7-6-24(20)35-13-3-1-2-10-33-23-17-34-19(15-22(23)31)16-30-8-11-32-12-9-30;;/h4-7,14-15,17H,1-3,8-13,16H2;2*1H

InChI key

LSECOAJFCKFQJG-UHFFFAOYSA-N

Descripción

Application

EHT 1864 has been used to study the regulation of the adapter protein dishevelled-1 ubiquitylation by Rac1 activity.

Biochem/physiol Actions

EHT 1864 inhibits Rac function.

EHT 1864 inhibits Rac function. It prevents Aβ40 and Aβ42 production in vitro without direct inhibition of g-secretase.

EHT 1864 induces dissociation of bound nucleotides. EHT 1864 induced inhibition of Rac prevents its association with downstream effectors. It is known to prevent estrogen-induced tumor cell proliferation in breast cancer.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GTP Binding Proteins (Low Molecular Weight) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

EHT 1864 compound sold under license from ExonHit Therapeutics S.A. (www.exonhit.com)

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Este artículo	S3944	SML0807	SML1691
Sigma-Aldrich E1657 EHT 1864	Sigma-Aldrich S3944 SEW2871	Sigma-Aldrich SML0807 PreQ1 dihydrochloride	Sigma-Aldrich SML1691 ZM323881 hydrochloride
description ≥98% (HPLC)	description ≥98% (HPLC), solid	description ≥98% (HPLC)	description ≥98% (HPLC)
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form powder	form solid	form powder	form powder
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility H₂O: 10 mg/mL, clear	solubility DMSO: ≥10 mg/mL, H₂O: insoluble	solubility DMSO: 5 mg/mL, clear (warmed)	solubility DMSO: 10 mg/mL, clear
color white to beige	color white	color white to light brown	color white to beige

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number

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