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D7071

Sigma-Aldrich

Dapoxetine hydrochloride

≥98% (HPLC)

Sinónimos:

(S)-N,N-dimethyl-1-phenyl-3-(1-naphthalenyloxy)propanamine hydrochloride, S-(+)-N,N-dimethyl-a-[2-(naphthalenyloxy)ethyl] benzenemethanamine hydrochloride, LY-210448 hydrochloride

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About This Item

Fórmula empírica (notación de Hill):
C21H23NO · HCl
Número de CAS:
129938-20-1
Peso molecular:
341.87
Número MDL:
MFCD08272809
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
329798842
NACRES:
NA.77

Análisis

≥98% (HPLC)

formulario

powder

actividad óptica

[α]/D +125 to +135°, c = 1 in methanol

condiciones de almacenamiento

desiccated

color

white

solubilidad

DMSO: ≥20 mg/mL

emisor

Eli Lilly

temp. de almacenamiento

room temp

cadena SMILES

Cl.CN(C)[C@@H](CCOc1cccc2ccccc12)c3ccccc3

InChI

1S/C21H23NO.ClH/c1-22(2)20(18-10-4-3-5-11-18)15-16-23-21-14-8-12-17-9-6-7-13-19(17)21;/h3-14,20H,15-16H2,1-2H3;1H/t20-;/m0./s1

Clave InChI

IHWDIQRWYNMKFM-BDQAORGHSA-N

Información sobre el gen

human ... SLC6A4(6532)

Descripción general

Dapoxetine ((+)-(S)-N,N-dimethyl-(α)-[2(1naphthal enyloxy)ethyl]-benzenemethanamine hydrochloride) possess a similar structure as that of fluoxetine.

Acciones bioquímicas o fisiológicas

Dapoxetine is capable of blocking recombinant Kv4.3 potassium voltage-gated channels. It is considered as safe.
Potent Selective serotonin reuptake inhibitor (SSRI); used in treatment of premature ejaculation

Características y beneficios

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogramas

Exclamation mark
GHS07

Palabra de señalización

Warning

Frases de peligro

H302,H319,H413

Clasificaciones de peligro

Acute Tox. 4 Oral - Aquatic Chronic 4 - Eye Irrit. 2

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Stanley E Althof et al.
The journal of sexual medicine, 7(6), 2243-2252 (2010-04-07)
The Clinical Global Impression of Change (CGIC) measures have high utility in clinical practice. However, it is unknown whether the CGIC is valued for assessing premature ejaculation (PE) symptoms and/or the relationship between CGIC and other validated PE patient-reported measures.
Tae Kon Kim et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 926, 42-46 (2013-04-02)
In this study, we describe and validate a rapid and sensitive method for quantitation of dapoxetine in rat plasma by using ultra-performance liquid chromatography-electrospray ionization tandem mass spectrometry (UPLC-ESI/MS/MS). Plasma samples were prepared by protein precipitation with acetonitrile, and sildenafil
Pierre Clément et al.
The journal of sexual medicine, 9(10), 2562-2573 (2012-08-22)
A brain network specifically activated when ejaculation occurs has been described in rats. Increasing serotonin (5-hydroxytryptamine [5-HT]) tone impairs ejaculation and chronic 5-HT selective serotonin reuptake inhibitors (SSRIs) are known to inhibit ejaculation. However, efficacy of acute treatment with SSRI
Imju Jeong et al.
European journal of pharmacology, 805, 36-45 (2017-03-23)
Selective serotonin reuptake inhibitors (SSRIs) have an inhibitory effect on various ion channels including Ca
Sheridan M Hoy et al.
Drugs, 70(11), 1433-1443 (2010-07-10)
Dapoxetine, a selective serotonin reuptake inhibitor, is the first oral pharmacological agent indicated for the treatment of men aged 18-64 years with premature ejaculation. In four randomized, double-blind, placebo-controlled, multicentre studies of 12-24 weeks' duration, oral dapoxetine 30 or 60
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