D4008

Dansylcadaverine

≥97% (TLC)

• Sinónimos: N-(5-Amino­pentyl)-5-di­methyl­amino­naphtha­lene-1-sulfon­amide, N-(Dimethyl­amino­naphtha­lene­sulfonyl)-1,5-pentane­diamine, Monodansyl cadaverine
• Fórmula empírica (notación de Hill): C₁₇H₂₅N₃O₂S
• Número de CAS: 10121-91-2
• Peso molecular: 335.46
• Beilstein: 2951070
• Número CE: 233-326-9
• Número MDL: MFCD00042704
• Código UNSPSC: 12352108
• ID de la sustancia en PubChem: 24893805
• NACRES: NA.32

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥97% (TLC)
• Formulario: powder
• temp. de almacenamiento: −20°C
• cadena SMILES: CN(C)c1cccc2c(cccc12)S(=O)(=O)NCCCCCN
• InChI: 1S/C17H25N3O2S/c1-20(2)16-10-6-9-15-14(16)8-7-11-17(15)23(21,22)19-13-5-3-4-12-18/h6-11,19H,3-5,12-13,18H2,1-2H3
• Clave InChI: MLEBFEHOJICQQS-UHFFFAOYSA-N

Descripción

Descripción general

Dansylcadaverine, also called as monodansylcadaverine (MDC), is a lysosomotropic agent. It is present in acidic and lipid rich regions. Dansylcadaverine also acts as a solvent polarity probe. It inhibits vesicular transport and decreases the rotavirus sequestering in L cells, when pre-treated.

Aplicación

Dansylcadaverine in methanol has a reported λex of 335 nm and λem of 512 nm. It has been used:

• as an endocytosis inhibitor in human proximal tubular HK-2 cells,(62) mouse J774A.1 macrophages and human A549 epithelial cells(63)
• to label autophagic vacuoles in cardiomyocytes for fluorescence microscopy studies(64)
• in monodansylcadaverine (MDC) staining of fibroblasts in Ankylosing spondylitis (AS) samples(65)

Acciones bioquímicas o fisiológicas

The autofluorescent dye dansylcadaverine, or monodansylcadaverine (MDC), is commonly used to monitor autophagy. MDC preferentially accumulates in autophagic vacuoles due to a combination of ion trapping and specific interactions with membrane lipids.

Envase

Bottomless glass bottle. Contents are inside inserted fused cone.

air sensitive, handled under inert gas

Otras notas

Solubility of dansylcadaverine is tested in methanol (10 mg/mL). It has also been reported that dansylcadaverine is soluble in DMSO and acetic acid.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H315,H319,H335
• Consejos de prudencia: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Clasificaciones de peligro: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órganos de actuación: Respiratory system
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves