30432

Dansylcadaverine

BioReagent, suitable for fluorescence, ≥99.0% (HPLC)

• Sinónimos: N-(5-Amino­pentyl)-5-di­methyl­amino­naphtha­lene-1-sulfon­amide, N-(Dimethyl­amino­naphtha­lene­sulfonyl)-1,5-pentane­diamine, Monodansyl cadaverine
• Fórmula empírica (notación de Hill): C₁₇H₂₅N₃O₂S
• Número CAS: 10121-91-2
• Peso molecular: 335.46
• UNSPSC Code: 12352108
• NACRES: NA.32
• PubChem Substance ID: 57648439
• EC Number: 233-326-9
• Beilstein/REAXYS Number: 2951070
• MDL number: MFCD00042704

Propiedades

• product line: BioReagent
• Quality Segment: 100
• assay: ≥99.0% (HPLC)
• mp: 137-140 °C
• fluorescence: λ_ex 335 nm; λ_em 518 nm in methanol, λ_ex 338 nm; λ_em 500 nm (Reaction product)
• suitability: suitable for fluorescence
• storage temp.: −20°C
• SMILES string: CN(C)c1cccc2c(cccc12)S(=O)(=O)NCCCCCN
• InChI: 1S/C17H25N3O2S/c1-20(2)16-10-6-9-15-14(16)8-7-11-17(15)23(21,22)19-13-5-3-4-12-18/h6-11,19H,3-5,12-13,18H2,1-2H3
• InChI key: MLEBFEHOJICQQS-UHFFFAOYSA-N

Descripción

Application

Dansylcadaverine (MDC), an autofluorescent dye, is used to monitor autophagy. MDC accumulates in autophagic vacuoles due to a combination of ion trapping and specific interactions with membrane lipids.

Biochem/physiol Actions

Inhibitor of the fibrin-stabilizing fator;[1] Inhibitor of epidermal growth factor (EGF) internalization;[2] Fluorescent substrate for the assay of transamidating enzymes.[3][4]

The autofluorescent dye dansylcadaverine, or monodansylcadaverine (MDC), is commonly used to monitor autophagy. MDC preferentially accumulates in autophagic vacuoles due to a combination of ion trapping and specific interactions with membrane lipids.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

air sensitive, handled under inert gas

Other Notes

Solubility of dansylcadaverine is tested in methanol (10 mg/mL). It has also been reported that dansylcadaverine is soluble in DMSO and acetic acid.

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves