D1068

DCB

≥98% (HPLC), solid

• Sinónimos: 3,3′-Dichlorobenzaldazine, NSC 67224
• Fórmula empírica (notación de Hill): C₁₄H₁₀Cl₂N₂
• Número CAS: 6971-97-7
• Peso molecular: 277.15
• NACRES: NA.77
• PubChem Substance ID: 24724458
• UNSPSC Code: 12352200
• MDL number: MFCD00556081
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: desiccated, under inert gas

Propiedades

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated, under inert gas
• color: yellow
• solubility: DMSO: ~6.8 mg/mL, H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: Clc1cccc(\C=N\N=C\c2cccc(Cl)c2)c1
• InChI: 1S/C14H10Cl2N2/c15-13-5-1-3-11(7-13)9-17-18-10-12-4-2-6-14(16)8-12/h1-10H/b17-9+,18-10+
• InChI key: XMOVWXSCYLINBJ-BEQMOXJMSA-N

Descripción

Biochem/physiol Actions

3,3′-dichlorobenzaldazine (DCB) serves as an allosteric ligand with neutral cooperativity. It helps to block the positive allosteric regulation of mGluRs (metabotropic glutamate receptor subtype 5 (mGluR5) with the help of 3,3′-difluorobenzaldazine (DFB) and the negative modulatory effect of 3,3′-dimethoxybenzaldazine (DMeOB).

Neutral allosteric modulator of the metabotropic glutamate receptor mGluR₅.

Features and Benefits

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• pictograms: GHS05,GHS07,GHS09
• signalword: Danger
• hcodes: H302,H315,H317,H318,H335,H410
• pcodes: P261 - P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• target_organs: Respiratory system
• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves