C9625

L-Carnosine

~99%

• Sinónimos: β-Alanyl-L-histidine
• Fórmula empírica (notación de Hill): C₉H₁₄N₄O₃
• Número de CAS: 305-84-0
• Peso molecular: 226.23
• Beilstein: 87671
• Número CE: 206-169-9
• Número MDL: MFCD00005207
• Código UNSPSC: 12352209
• ID de la sustancia en PubChem: 24893178
• NACRES: NA.26

Propiedades

• product name: L-Carnosine, ~99%, crystalline
• Análisis: ~99%
• formulario: crystalline
• color: white to off-white
• mp: 253 °C (dec.) (lit.)
• aplicaciones: cell analysis
• temp. de almacenamiento: −20°C
• cadena SMILES: NCCC(=O)N[C@@H](Cc1c[nH]cn1)C(O)=O
• InChI: 1S/C9H14N4O3/c10-2-1-8(14)13-7(9(15)16)3-6-4-11-5-12-6/h4-5,7H,1-3,10H2,(H,11,12)(H,13,14)(H,15,16)/t7-/m0/s1
• Clave InChI: CQOVPNPJLQNMDC-ZETCQYMHSA-N
• Información sobre el gen: human ... CA1(759) , CA2(760)

Descripción

Amino Acid Sequence

Ala-His

Aplicación

L-Carnosine has been used to study its effects as an antioxidant on meat quality of pigs. It has also been used to study its effects on brain injury in a rat intracerebral hemorrhage model.

Acciones bioquímicas o fisiológicas

L-Carosine is a dipeptide found at millimolar concentration in brain, muscle and the lens of the eye. In model systems it is a potent antioxidant that scavenges oxygen free radicals and transition metal ions. It blocks protein-protein and protein-DNA cross-links induced by hypochlorite anions and toxic aldehydes such as acetaldehyde, formaldehyde, and malondialdehyde, the primary product of lipid peroxidation. It also inhibits nonenzymatic protein glycation induced by aldose and ketose reducing sugars and inhibits the formation of toxic advanced glycation end products (AGE). These activities make it of interest in studies of aging, atherosclerosis, Alzheimer′s disease, and the secondary effects of diabetes.

Dipeptide with potent antioxidant and antiglycation activity; blocks nonenzymatic glycosylation and protein cross-linking induced by reactive aldehydes.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)