C3116
Anti-CXCR4 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Sinónimos:
Anti-CXC Chemokine Receptor 4
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About This Item
Número MDL:
Código UNSPSC:
51111800
Productos recomendados
origen biológico
rabbit
Nivel de calidad
conjugado
unconjugated
forma del anticuerpo
affinity isolated antibody
tipo de anticuerpo
primary antibodies
clon
polyclonal
Formulario
buffered aqueous solution
reactividad de especies
human
técnicas
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 9-14 μg/mL
Nº de acceso UniProt
Condiciones de envío
dry ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... CXCR4(7852)
mouse ... Cxcr4(12767)
rat ... Cxcr4(60628)
Inmunógeno
synthetic peptide corresponding to the third cytoplasmic loop of human CXC chemokine receptor 4 (CXCR4), conjugated to KLH. The immunizing peptide has 100% homology with the rat and mouse gene.
Aplicación
Anti-CXCR4 antibody produced in rabbit is suitable for immunohistochemistry of formalin-fixed, paraffin-embedded tissue sections at a working concentration of 9-14 μg/mL. It was used to stain rat bladder sections at a dilution of 1:2000, incubated overnight.
Acciones bioquímicas o fisiológicas
CXCR4 is a cell surface receptor of the chemokine CXCL12 (SDF-1) and is involved in metastasis, hematopoiesis and immune responses. It acts with CD4 to facilitate the entry of HIV into target cells. CXCR4 has important roles in tumor initiation, proliferation, invasion and metastasis of breast cancer cells.
Forma física
Solution in phosphate buffered saline, containing 0.1% sodium azide.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
nwg
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Angelo Ferrari et al.
BMC veterinary research, 8, 27-27 (2012-03-16)
Mammary tumours frequently develop in female domestic cats being highly malignant in a large percentage of cases. Chemokines regulate many physiological and pathological processes including organogenesis, chemotaxis of inflammatory cells, as well as tumour progression and metastasization. In particular, the
M J Walters et al.
British journal of cancer, 110(5), 1179-1188 (2014-01-16)
In experimental models of glioblastoma multiforme (GBM), irradiation (IR) induces local expression of the chemokine CXCL12/SDF-1, which promotes tumour recurrence. The role of CXCR7, the high-affinity receptor for CXCL12, in the tumour's response to IR has not been addressed. We
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Veterinary research communications, 47(3), 1615-1627 (2023-04-11)
Canine Soft Tissue Sarcoma (STS) cell line A-72 has been largely employed for antiviral and antiproliferative studies. However, there are few information on their characteristics. Our aim was to evaluate A-72 expression level of genes and proteins involved in the
Pedro L Vera et al.
PloS one, 3(12), e3898-e3898 (2008-12-11)
Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine involved in cystitis and a non-cognate ligand of the chemokine receptor CXCR4 in vitro. We studied whether CXCR4-MIF associations occur in rat bladder and the effect of experimental cystitis. Twenty male
Amnon Peled et al.
Theranostics, 3(1), 34-39 (2013-02-06)
The Chemokine receptor CXCR4 and its ligand stromal derived factor-1 (SDF-1/CXCL12) are important players involved in cross-talk between leukemia cells and the bone marrow (BM) microenvironment. CXCR4 expression is associated with poor prognosis in AML patients with and without the
Artículos
Cancer stem cell media, spheroid plates and cancer stem cell markers to culture and characterize CSC populations.
Filtros activos
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