C2538

Carboplatin

• Sinónimos: cis-Diammine(1,1-cyclobutanedicarboxylato) platinum
• Fórmula lineal: [C₄H₆(CO₂)₂]Pt(NH₃)₂
• Número de CAS: 41575-94-4
• Peso molecular: 371.25
• Número CE: 255-446-0
• Número MDL: MFCD00070464
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24278303
• NACRES: NA.77

Propiedades

• Formulario: powder
• Nivel de calidad: 100
• espectro de actividad antibiótica: neoplastics
• emisor: Bristol-Myers Squibb
• cadena SMILES: N.N.O=C1O[Pt]OC(=O)C12CCC2
• InChI: 1S/C6H8O4.2H3N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H3;/q;;;+2/p-2
• Clave InChI: OLESAACUTLOWQZ-UHFFFAOYSA-L

Descripción

Descripción general

Carboplatin is used to treat testicular, ovarian and breast cancer.[1]

Aplicación

Carboplatin has been used:

• in chemotherapy-induced thrombocytopenia mouse model and treatment[2]
• to induce cell death in a large subset of colorectal cancer cells[3]
• in the evaluation of cell proliferation and chemosensitivity[4]
• as a positive control for suppressed cell growth[5]

Acciones bioquímicas o fisiológicas

Carboplatin is a platinum-based antineoplastic drug that damages DNA by forming intrastrand cross-links with neighboring guanine residues. Tumors acquire resistance to these drugs through the loss of DNA-mismatch repair (MMR) activity and the resultant decrease in the induction of programmed cell death.

Características y beneficios

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Pictogramas: GHS08,GHS07
• Palabra de señalización: Danger
• Frases de peligro: H302 + H312 + H332,H317,H334,H340,H360
• Consejos de prudencia: P202 - P261 - P280 - P301 + P312 - P302 + P352 + P312 - P308 + P313
• Clasificaciones de peligro: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Muta. 1B - Repr. 1B - Resp. Sens. 1 - Skin Sens. 1
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges