C0292

Calcitonin Gene Related Peptide rat

≥95% (HPLC), powder

• Sinónimos: α-CGRP, CGRP-I
• Fórmula empírica (notación de Hill): C₁₆₂H₂₆₂N₅₀O₅₂S₂
• Número de CAS: 96827-03-1
• Peso molecular: 3806.25
• Número MDL: MFCD00081460
• Código UNSPSC: 51111800
• NACRES: NA.32

Propiedades

• origen biológico: rat
• Nivel de calidad: 200
• Ensayo: ≥95% (HPLC)
• Formulario: powder
• mol peso: 3803.25-3809.25 Da
• técnicas: cell based assay: suitable
• nota de secuencia: Ser-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2
• Nº de acceso UniProt: P01257; P01256
• temp. de almacenamiento: −20°C
• Información sobre el gen: rat ... Calca(24241)

Descripción

Amino Acid Sequence

Ser-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2

Descripción general

Research area: Neuroscience

Calcitonin gene related peptide (CGRP) is a 37 amino acid neuropeptide. It exists in two isoforms α-CGRP and β-CGRP. CGRP is produced by the alternative splicing of the calcitonin gene (CALCA).[1] They are primarily localized in the C and Aδ sensory fibers, [2] but are also present in non-neuronal tissues, like the cardiovascular system.[3]

Aplicación

Calcitonin Gene Related Peptide rat has been used:

• To study its protective role in lipopolysaccharide (LPS)-induced acute lung injury (ALI).[4]
• To examine the effects of calcitonin gene related peptide (CGRP) and salmon calcitonin (sCT) on gastric lesions and mucosal barrier in stress induced rats.[5]
• To mediate the complement component 5a (C5a) induced mechanical hypersensitivity by activating nerve fibers and influencing non-neuronal cell movement through its receptor. [6][5]

Acciones bioquímicas o fisiológicas

Calcitonin gene related peptide (CGRP) is a potent vasodilator produced from sensory fibers, acting as transmitters in the peripheral and central nervous system[7], thereby exerting its role in regulating pain and cardiovascular activity[1]. CGRPs play an important role in regulating systemic blood pressure, and microvascular dilatation[1] and are associated with hyperemia. It stimulates edema in orofacial tissue[8] and its activation in pancreatic β-cells increases plasma levels of pancreatic enzymes. In addition, CGRP also induces DNA synthesis and cell proliferation in endothelial cells.[9]

Potent, long-lasting vasodilator.

Potent, long-lasting vasodilator; activation of CGRP receptors on pancreatic β-cells increases plasma levels of pancreatic enzymes.

Otras notas

Lyophilized from 0.1% TFA in H2O

Información de seguridad

• Código de clase de almacenamiento: 13 - Non Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)