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A1439

Pituitary adenylate cyclase activating polypeptide-38

Sinónimos:

PACAP-38

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Talla/SKUDisponibilidadPrecio
0.1 mg
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333,00 €

Acerca de este artículo

Fórmula empírica (notación de Hill):
C203H331N63O53S
Número CAS:
Peso molecular:
4534.26
UNSPSC Code:
41106305
NACRES:
NA.32
MDL number:
Form:
powder

333,00 €


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form

powder

Quality Segment

composition

Peptide content, ~70%

UniProt accession no.

storage temp.

−20°C

Gene Information

human ... ADCYAP1(116)

General description

Pituitary adenylate cyclase activating polypeptide-38 (PACAP38) is mapped to human chromosome 18. 27-residue-amidated fragment (PACAP27) comprises another isoform. The PACAP38 is major isoform associated with mammals.

Application

Pituitary adenylate cyclase activating polypeptide-38 has been used to test its effect in stimulating the formation of cyclic AMP hypothalamus and cerebral cortex slices of chicken and to treat glioblastoma cells (U87MG) in cell migration assay to test its anti-invasive effects.

Biochem/physiol Actions

Pituitary adenylate cyclase activating polypeptide-38 (PACAP38) is a cardioprotectant and may help in treating radiation-induced heart disease (RIHD). It plays a protective role during oxidative stress in cardiomyocytes. PACAP38 has antioxidant, anti-apoptotic and anti-inflammatory property. It is implicated in the pathophysiology of migraine and cluster headache.
PACAP-38 is a neuropeptide that has substantial sequence homology to vasoactive intestinal peptide (VIP). It is reported to serve as a neuronal survival factor.

Other Notes

Lyophilized from 0.1% TFA in H2O

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Este artículo
F5392P1167SRP8038
description

-

description

FGF-Basic, suitable for cell culture

description

lyophilized powder, suitable for cell culture

description

recombinant, expressed in E. coli, FLAG® tagged, >95% (SDS-PAGE)

form

powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

Gene Information

human ... ADCYAP1(116)

Gene Information

bovine ... FGF2(281161)

Gene Information

-

Gene Information

mouse ... Il1f10(215274)

UniProt accession no.

P18509

UniProt accession no.

P03969

UniProt accession no.

-

UniProt accession no.

Q8R459

composition

Peptide content, ~70%

composition

-

composition

-

composition

-


Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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Preguntas

  1. How can stock solutions for item A1439, Pituitary adenylate cyclase activating polypeptide-38, be reconstituted and stored?

    1 respuesta
    1. The solubility information can be found on the Specification sheet: Solubility (Solvent) Water or 1% Acetic Acid Solubility (Conc) 1.00 - 1.04 mg/ml. Stock solutions are stable for up to 3 months at -20°C.

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