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A6150

Sigma-Aldrich

α1-Antitrypsin from human plasma

salt-free, lyophilized powder

Sinónimos:

α1-Proteinase inhibitor

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About This Item

Número de CAS:
9041-92-3
Número CE:
232-924-7
Número MDL:
MFCD00130469
Código UNSPSC:
12352202
NACRES:
NA.77

origen biológico

human plasma

Nivel de calidad

200

formulario

salt-free, lyophilized powder

concentración

≥60% (biuret)

técnicas

inhibition assay: suitable

Nº de acceso UniProt

P01009
P08246

temp. de almacenamiento

2-8°C

Información sobre el gen

human ... ELA2(1991) , ELANE(1991) , SERPINA1(5265)

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Acciones bioquímicas o fisiológicas

Serine protease inhibitor; inhibits trypsin, chymotrypsin and pancreatic and granulocytic elastase, and acrosin. Effective concentration equimolar with proteinase.The effects of hereditary α1-antitrypsin deficiency and certain autoimmune states result from uncontrolled proteolysis in vivo. Direct α1-antitrypsin replacement therapy has shown promise in animal models of Type 1 diabetes.
≤10 mg will inhibit 1.0 mg of trypsin with activity of 10,000 BAEE units per mg protein. ≤10 mg will inhibit approx. 1.0 mg of ·α-chymotrypsin with activity of 40-50 BTEE units per mg protein.

Precaución

Aqueous stock solutions containing 0.01% NaN3 are stable for several months. Solutions can be stored at −80 °C, but should not be refrozen. Unstable below pH 5.5. Inactivated by some non-serine proteinases and by oxidation of active site methionine residue.

Nota de preparación

Chromatographically prepared and partially purified.

Cláusula de descargo de responsabilidad

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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J M Bender et al.
Experimental mechanics, 61(1), 235-251 (2021-03-30)
Myxomatous mitral valve degeneration is a common cause of mitral regurgitation and is often associated with mitral valve prolapse. With no known targets to pharmacologically treat mitral valve prolapse, surgery is often the only treatment option. Recently, radiofrequency ablation has
Kathirvel Alagesan et al.
Analytical and bioanalytical chemistry, 409(2), 529-538 (2016-12-03)
Glycopeptide enrichment is a crucial step in glycoproteomics for which hydrophilic interaction chromatography (HILIC) has extensively been applied due to its low bias towards different glycan types. A systematic evaluation of applicable HILIC mobile phases on glycopeptide enrichment efficiency and
Leslie W Chan et al.
Nature nanotechnology, 15(9), 792-800 (2020-07-22)
Human breath contains many volatile metabolites. However, few breath tests are currently used in the clinic to monitor disease due to bottlenecks in biomarker identification. Here we engineered breath biomarkers for respiratory disease by local delivery of protease-sensing nanoparticles to
Cynthia L Bristow et al.
Journal of immunology (Baltimore, Md. : 1950), 180(1), 492-499 (2007-12-22)
To identify positive or negative factors for HIV-1 infectivity, clones from the U937 promonocytic cell line that express similar levels of CD4 and CXCR4, but differ in HIV-1 susceptibility, were compared. In contrast to HIV-1 permissive clone 10 (plus), nonpermissive
Yukako Oda et al.
Science advances, 7(47), eabj6895-eabj6895 (2021-11-18)
[Figure: see text].
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