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A9024

α1-Antitrypsin from human plasma

salt-free, lyophilized powder

Sinónimos:

α1-Proteinase inhibitor

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Talla/SKUDisponibilidadPrecio
5 mg
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272,00 €
25 mg
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945,00 €

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Número CAS:
UNSPSC Code:
12352202
EC Number:
232-924-7
NACRES:
NA.77
MDL number:

272,00 €


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biological source

human plasma

Quality Segment

assay

≥70% protein basis (biuret)

form

salt-free, lyophilized powder

UniProt accession no.

storage temp.

2-8°C

Gene Information

Biochem/physiol Actions

1-4 mg will inhibit 1.0 mg of trypsin with activity of approx. 10,000 BAEE units per mg protein. 1-6 mg will inhibit 1.0 mg of α-chymotrypsin with activity of >=40 BTEE units per mg protein.
Serine protease inhibitor; inhibits trypsin, chymotrypsin and pancreatic and granulocytic elastase, and acrosin. Effective concentration equimolar with proteinase.
Serine protease inhibitor; inhibits trypsin, chymotrypsin and pancreatic and granulocytic elastase, and acrosin. Effective concentration equimolar with proteinase.The effects of hereditary α1-antitrypsin deficiency and certain autoimmune states result from uncontrolled proteolysis in vivo. Direct α1-antitrypsin replacement therapy has shown promise in animal models of Type 1 diabetes.

Preparation Note

Chromatographically prepared and partially purified.

Disclaimer

Aqueous stock solutions containing 0.01% NaN3 are stable for several months. Solutions can be stored at −80 °C, but should not be refrozen. Unstable below pH 5.5. Inactivated by some non-serine proteinases and by oxidation of active site methionine residue.
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

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Este artículo
A2221178251SAB4200198
description

salt-free, lyophilized powder

description

lyophilized powder, ≥95% (SDS-PAGE)

description

α1-Antitrypsin, CAS 9041-92-3, is a protease inhibitor of the serpin superfamily. Inhibits elastase, cathepsin G, and proteinase 3.

description

clone 1C2, purified from hybridoma cell culture

assay

≥70% protein basis (biuret)

assay

≥95% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

assay

-

biological source

human plasma

biological source

human plasma

biological source

-

biological source

mouse

Gene Information

human ... ELA2(1991), SERPINA1(5265)

Gene Information

human ... SERPINC1(462)

Gene Information

-

Gene Information

human ... SERPINA1(5265)

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

-

form

salt-free, lyophilized powder

form

lyophilized powder

form

solid

form

buffered aqueous solution

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C


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Clase de almacenamiento

11 - Combustible Solids

¿Qué está pasando?

WGK 3

Punto de inflamación (°F)

Not applicable

Punto de inflamación (°C)

Not applicable



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Preguntas

1–2 de 2 Preguntas  
  1. What is the Department of Transportation shipping information for this product?

    1 respuesta
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  2. What is the carbohydrate content of human alpha-1-Antitrypsin?

    1 respuesta
    1. We have found the information on alpha-1-antitrypsin in a reference book:The Plasma Proteins, F.W. Putnam, ed, volume 2, chapter 4, Table II.The alpha-1-antitrypsin is 12 percent carbohydrate, citing K. Heide and H.G. Schwick, Chemistry and Significance of the Carbohydrate Moieties of Human Serum Glycoproteins, Angew. Chem., Int. Ed. Eng., 12, 721-733 (1973).The table also gives information on the percentage of each type of monosaccharide that is present.

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