A1755

Aminophylline dihydrochloride hyderate

≥98%, powder

• Sinónimos: (Theophylline)₂ · Ethylenediamine, 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione, cmpd. with 1,2-ethanediamine (2:1), Theophylline hemiethylenediamine complex
• Fórmula empírica (notación de Hill): C₇H₈N₄O₂ · 0.5C₂H₈N₂
• Número de CAS: 317-34-0
• Peso molecular: 210.21
• Número CE: 206-264-5
• Número MDL: MFCD00013221
• Código UNSPSC: 41106305
• ID de la sustancia en PubChem: 24277691
• NACRES: NA.77

Propiedades

• Ensayo: ≥98%
• Formulario: powder
• color: white to off-white
• solubilidad: H₂O: 50 mg/mL (solutions should be freshly prepared.); alcohol: insoluble
• temp. de almacenamiento: −20°C
• cadena SMILES: NCCN.CN1C(=O)N(C)c2nc[nH]c2C1=O.CN3C(=O)N(C)c4nc[nH]c4C3=O
• InChI: 1S/2C7H8N4O2.C2H8N2/c2*1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;3-1-2-4/h2*3H,1-2H3,(H,8,9);1-4H2
• Clave InChI: FQPFAHBPWDRTLU-UHFFFAOYSA-N
• Información sobre el gen: human ... ADORA1(134) , ADORA2A(135) , ADORA2B(136) , ADORA3(140) , PDE3A(5139) , PDE3B(5140) , PDE4A(5141) , PDE4B(5142) , PDE4C(5143) , PDE4D(5144)

Descripción

Aplicación

Aminophylline has been used:

• as a positive control in the selective inhibitor of nuclear export, KPT-350 zebrafish dosing experiments[1]
• as a positive control for the determination of the spasmolytic activity of C. aeruginosa extracts[2]
• as a phosphodiesterase (PDE) inhibitor in inhibitor studies to quantify its potency to inhibit PDE4A1A and PDE3A enzyme in an assay[3]

Acciones bioquímicas o fisiológicas

Aminophylline is a methylxanthine compound containing theophylline andethylenediamine in a ratio of 2:1. It acts as a bronchodilator and is used to treat chronic lung diseases like asthma, bronchitis, or emphysema.[4]

Non-selective phosphodiesterase (PDE) inhibitor. Antiepileptic drug

Información de seguridad

• Pictogramas: GHS06
• Palabra de señalización: Danger
• Frases de peligro: H301
• Consejos de prudencia: P264 - P270 - P301 + P310 - P405 - P501
• Clasificaciones de peligro: Acute Tox. 3 Oral
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Faceshields, Gloves