87128

Tetracycline

98.0-102.0% (HPLC)

• Sinónimos: Tetracycline HCL, Tetracycline Monohydrochloride
• Fórmula empírica (notación de Hill): C₂₂H₂₄N₂O₈ · xH₂O
• Número de CAS: 60-54-8
• Peso molecular: 444.43 (anhydrous basis)
• Beilstein: 2230417
• Número CE: 200-481-9
• Número MDL: MFCD00151232
• Código UNSPSC: 51284017
• ID de la sustancia en PubChem: 57653229
• NACRES: NA.85

Propiedades

• origen biológico: synthetic
• Análisis: 98.0-102.0% (HPLC)
• formulario: powder or crystals
• color: faint yellow to dark yellow
• mp: 172-174 °C (dec.)
• espectro de actividad antibiótica: Gram-negative bacteria; Gram-positive bacteria
• Modo de acción: protein synthesis | interferes
• temp. de almacenamiento: 2-8°C
• cadena SMILES: CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)cccc4[C@@]3(C)O
• InChI: 1S/C22H24N2O8/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30)/t9-,10-,15-,21+,22-/m0/s1
• Clave InChI: OFVLGDICTFRJMM-WESIUVDSSA-N
• Información sobre el gen: human ... CYP1A2(1544) , TERT(7015)

Descripción

Descripción general

Chemical structure: tetracycline

Acciones bioquímicas o fisiológicas

Mode of Action: Tetracycline passively diffuses through proin channels in the cell membrane, binding to 30S ribosomes and inhibits protein synthesis by preventing access of aminoacyl tRNA to the acceptor site on the mRNA-ribosome complex. It also binds to the bacterial 50S ribosomal subunit, altering the membrane and causing intracellular components to leak from bacterial cells. The inhibitory effects can be reversed by washing, suggesting that it is the reversibly bound antibiotic, and not the irreversibly bound drug, that is responsible for antibacterial action.

Mode of Resistance: The effects are inactivated via a loss of cell wall permeability.

Antimicrobial spectrum: Includes a wide range of antimicrobial activity against gram-positive and gram-negative bacteria.

Envase

25g, 100g

Otras notas

Keep container tightly closed in a dry and well-ventilated place.Hygroscopic. Light sensitive. Keep in a dry place.

Información de seguridad

• Pictogramas: GHS08,GHS07,GHS09
• Palabra de señalización: Warning
• Frases de peligro: H302,H361fd,H411
• Consejos de prudencia: P202 - P264 - P273 - P280 - P301 + P312 - P308 + P313
• Clasificaciones de peligro: Acute Tox. 4 Oral - Aquatic Chronic 2 - Repr. 2
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves