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Merck

53370

L-histidina monohydrochloride monohydrate

≥99.0% (AT)

Sinónimos:

Ácido Lα-amino-β-(4-imidazolil) propiónico monohydrochloride

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Fórmula empírica (notación de Hill):
C6H9N3O2 · HCl · H2O
Número CAS:
Peso molecular:
209.63
UNSPSC Code:
12352209
NACRES:
NA.77
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
4168261
eCl@ss:
32160406
Assay:
≥99.0% (AT)
Form:
solid
Quality level:

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Quality Level

assay

≥99.0% (AT)

form

solid

optical activity

[α]20/D +9.5±0.5°, c = 5% in 5 M HCl

impurities

≤0.3% foreign amino acids

mp

254 °C (dec.) (lit.)

solubility

H2O: 1 g/10 mL, clear, colorless (hot)

anion traces

sulfate (SO42-): ≤100 mg/kg

cation traces

Ca: ≤10 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤5 mg/kg, K: ≤50 mg/kg, Mg: ≤5 mg/kg, Mn: ≤5 mg/kg, NH4+: ≤500 mg/kg, Na: ≤50 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Zn: ≤5 mg/kg

SMILES string

O.Cl.N[C@@H](Cc1c[nH]cn1)C(O)=O

InChI

1S/C6H9N3O2.ClH.H2O/c7-5(6(10)11)1-4-2-8-3-9-4;;/h2-3,5H,1,7H2,(H,8,9)(H,10,11);1H;1H2/t5-;;/m0../s1

InChI key

CMXXUDSWGMGYLZ-XRIGFGBMSA-N

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1 of 4

Este artículo
H8125H40361.04354
form

solid

form

-

form

powder

form

solid

assay

≥99.0% (AT)

assay

≥98% (HPLC)

assay

≥98.5%

assay

98.5-101.0% (alkalimetric), 99.0-101.0% (perchloric acid titration)

Quality Level

100

Quality Level

200

Quality Level

400

Quality Level

500

solubility

H2O: 1 g/10 mL, clear, colorless (hot)

solubility

H2O: 50 mg/mL, clear, colorless to very faintly yellow

solubility

H2O: 50 mg/mL

solubility

149.55 g/L

optical activity

[α]20/D +9.5±0.5°, c = 5% in 5 M HCl

optical activity

-

optical activity

-

optical activity

-

impurities

≤0.3% foreign amino acids

impurities

-

impurities

endotoxin, heavy metals, residual solvents, tested

impurities

-

General description

L-Histidine is a hydrophilic essential amino acid that has a basic sidechain containing an imidazole group.

Biochem/physiol Actions

L-Histidine is biosynthesized from ATP, 5-phosphoribosyl-1-pyrophosphate (PRPP), and glutamine. This essential amino acid can be degraded to glutamate by histidiase, urocanase and imidazolonepropionase; it is also the precursor of histamine by action of histidine decarboxylase.

Clase de almacenamiento

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Sean E Lehman et al.
Journal of pharmaceutical sciences, 110(5), 1948-1957 (2021-01-17)
Protein aggregation can affect the quality of protein-based therapeutics. Attempting to unravel factors influencing protein aggregation involves systematic studies. These studies often include sodium azide or similar preservatives in the aggregation buffer. This work shows effects of azide on aggregation
Biochemistry, 3rd. ed. (New York, NY)
Stryer, L., W.H. Freeman
Biochemistry (3rd Edition), 19-20 (1988)
Textbook of Biochemistry with Clinical Correlations, 5th ed. (New York, NY)
Devlin, T. M., ed., Wiley-Liss
Biochemistry (5th Edition), 97-97 (2002)
Karla Viridiana Castro-Cerritos et al.
Bio-protocol, 7(23), e2634-e2634 (2017-12-05)
Elucidating how a population of non-growing bacteria generates mutations improves our understanding of phenomena like antibiotic resistance, bacterial pathogenesis, genetic diversity and evolution. To evaluate mutations that occur in nutritionally stressed non-growing bacteria, we have employed the strain B. subtilis
Martin Maldonado et al.
Neurochemistry international, 85-86, 31-39 (2015-05-06)
The effect of reserpine on histamine (HA) and tele-methylhistamine (N(τ)-MHA) in hypothalamus and cortex of rats was analyzed and compared to catecholamines. IP injection of reserpine (5 mg/kg) confirmed the effectiveness of reserpine treatment on noradrenaline and dopamine levels. Our in-vitro

Número de artículo de comercio global

SKUGTIN
853026010004027269096748
15544-25G04061832593883
15544-5G04061838742056
853026002504027269096731
53370-1G-KC04061824272468
53370-100G04061835552191
53370-500G04061833439234
53370-25G04061835508457

Preguntas

1–2 de 2 Preguntas  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 respuesta
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 respuesta
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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