10817
Apolipoprotein A-I from human plasma
≥90% (GE)
Sinónimos:
Apo A-1
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About This Item
Productos recomendados
origen biológico
human plasma
Ensayo
≥90% (GE)
Formulario
lyophilized solid
mol peso
Mr ~28300
solubilidad
H2O: 1 mg/mL, clear, colorless
Nº de acceso UniProt
Condiciones de envío
dry ice
temp. de almacenamiento
−20°C
Información sobre el gen
human ... APOA1(335)
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Descripción general
Apolipoprotein A-I (apoA-I) is the chief protein component of high density lipoproteins (HDL) and a major determinant of HDL structure, composition, and stability. It is an exchangeable apolipoprotein and plays pivotal role in the metabolism of cholesterol. [1]
Aplicación
Acciones bioquímicas o fisiológicas
High-density lipoproteins are antiatherogenic and cardioprotective by facilitating reverse cholesterol transport (RCT). Some strategies for elevating apolipoprotein A-I levels are studied as therapies for atherosclerosis.
Nota de preparación
lyophilized from 0.01 M ammonium hydrogen carbonate
Otras notas
A principal protein component of high-density lipoproteins. Protein - lipid interactions[4]
Código de clase de almacenamiento
13 - Non Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Scott M Gordon et al.
Current opinion in endocrinology, diabetes, and obesity, 19(2), 109-114 (2012-01-27)
To review recently published advances in the development of apolipoprotein A-I (apoA-I) mimetic peptides as a potential treatment for cardiovascular diseases. Various apoA-I mimetic peptides are currently in development and these display potent cardioprotective features that can rival or even
Jens O Lagerstedt et al.
Biochimica et biophysica acta, 1821(3), 448-455 (2012-01-17)
Apolipoprotein A-I (apoA-I) is the major protein component of high density lipoproteins (HDL) and plays a central role in cholesterol metabolism. The lipid-free/lipid-poor form of apoA-I is the preferred substrate for the ATP-binding cassette transporter A1 (ABCA1). The interaction of
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Journal of lipid research, 51(9), 2560-2570 (2010-05-26)
The relationship between high-density lipoprotein and pulmonary function is unclear. To determine mechanistic relationships we investigated the effects of genetic deletion of apolipoprotein A-I (apoA-I) on plasma lipids, paraoxonase (PON1), pro-inflammatory HDL (p-HDL), vasodilatation, airway hyperresponsiveness and pulmonary oxidative stress
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Lipids in health and disease, 8, 27-27 (2009-07-25)
Haptoglobin is a plasma protein that scavenges haemoglobin during haemolysis. Phospholipid Transfer Protein (PLTP) transfers lipids from Low Density Lipoproteins (LDL) to High Density Lipoproteins (HDL). PLTP is involved in the pathogenesis of atherosclerosis which causes coronary artery disease, the
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