SBR00026

Ligstroside

Nitric oxide inhibitor, ≥95%

• Sinónimos: (-)-ligstroside, Ligustroside
• Fórmula empírica (notación de Hill): C₂₅H₃₂O₁₂
• Número de CAS: 35897-92-8
• Peso molecular: 524.51
• Código UNSPSC: 12352200
• NACRES: NA.25

Propiedades

• origen biológico: plant
• Nivel de calidad: 100
• Ensayo: ≥95%
• Formulario: lyophilized powder
• mol peso: 524.51
• solubilidad: DMSO: ≥10 mg/mL (19 mM); methanol: ≥10 mg/mL
• aplicaciones: metabolomics; vitamins, nutraceuticals, and natural products
• temp. de almacenamiento: −20°C
• InChI: 1S/C25H32O12/c1-3-15-16(10-19(28)34-9-8-13-4-6-14(27)7-5-13)17(23(32)33-2)12-35-24(15)37-25-22(31)21(30)20(29)18(11-26)36-25/h3-7,12,16,18,20-22,24-27,29-31H,8-11H2,1-2H3/b15-3+/t16-,18+,20+,21-,22+,24-,25-/m0/s1
• Clave InChI: GMQXOLRKJQWPNB-MVVLSVRYSA-N

Descripción

Descripción general

Ligstroside, also known as ligusroside, is a secoiridoid glycoside, a bioactive natural compound commonly derived from plants like Ligustrum lucidum, Jasminum officinale, and Osmanthus heterophyllus. Existing research suggests that this metabolite functions as an nitric oxide inhibitor and may exhibit diverse biological activities, including anti-neoplastic, antioxidant, antiviral, and anti-inflammatory properties.

Aplicación

Ligstroside is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.

Acciones bioquímicas o fisiológicas

Ligstroside is a natural product derived from leaves of Olea europaea. Ligstroside displays several potentially beneficial anti-inflammatory properties by exhibiting selective inhibition effect on COX-1 enzyme of arachidonate cascade metabolism. Ligstroside generates a reduction of the PGE₂ (prostaglandin E₂) levels in activated mouse macrophage (IC50 = 48.53 μM) and also reduction of the TXB₂ (thromboxane B₂) levels in human platelets (IC50 = 122.63 μM).^[1] Moreover, Ligstroside exhibits inhibition activity of NO production in LPS-activated RAW264.7 macrophages (17.8% at 30 μM and 40.7% at 100 μM) without any cytotoxic effect in these cells.^[2],[3] Additionally, Ligstroside exhibits in vitro antiviral activity against parainfluenza type 3 virus (IC50 = 15.6 μM).^[4]

Características y beneficios

• Suitable for Biochemical and Biomedical research
• Versatile and adaptable for wide variety of laboratory and research applications

Almacenamiento y estabilidad

Hygroscopic; store in dry place with desiccant

Otras notas

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Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable