PHR1789

Doxorrubicina hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

• Sinónimos: DOX, Hidroxidaunorrubicina hydrochloride
• Fórmula empírica (notación de Hill): C₂₇H₂₉NO₁₁ · HCl
• Número de CAS: 25316-40-9
• Peso molecular: 579.98
• Beilstein: 4229251
• Número CE: 246-818-3
• Número MDL: MFCD00077757
• Código UNSPSC: 41116107
• ID de la sustancia en PubChem: 329823614
• NACRES: NA.24

Propiedades

• grado: certified reference material; pharmaceutical secondary standard
• Nivel de calidad: 300
• Agency: traceable to BP 990; traceable to Ph. Eur. D2975000; traceable to USP 1225703
• familia API: doxorubicin
• formulario: powder
• CofA: current certificate can be downloaded
• envase: pkg of 200 mg
• técnicas: HPLC: suitable; gas chromatography (GC): suitable
• mp: 216 °C (dec.) (lit.)
• aplicaciones: pharmaceutical (small molecule)
• temp. de almacenamiento: -10 to -25°C
• cadena SMILES: Cl[H].COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
• InChI: 1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1
• Clave InChI: MWWSFMDVAYGXBV-RUELKSSGSA-N
• Información sobre el gen: human ... TOP2A(7153)

Descripción

Descripción general

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Doxorubicin Hydrochloride is an anthracycline antibiotic, known for its broad range anti-cancer activities.

Aplicación

This pharmaceutical secondary standard can also be used as follows:

• Development of a reversed-phase high-performance liquid chromatographic (RP-HPLC) method combined with UV detection to determine doxorubicin hydrochloride in plasma samples
• Electrochemical determination of doxorubicin by spinel-structured cobalt ferrite (CoFe₂O₄) modified carbon paste electrode in biological fluid and injection samples
• Determination of doxorubicin hydrochloride in human plasma samples using a graphene quantum dots (GQDs) based electrochemical sensor
• RP-HPLC method-based quantitative analysis of doxorubicin hydrochloride in vacuum foam dried formulations
• Voltammetric determination of doxorubicin hydrochloride and dastinib using zinc oxide (ZnO) nanoparticle/1-butyl-3-methylimidazolium tetra-fluoroborate modified carbon paste electrode (ZnO-NPs/BMTFB/CPE) in their combined injection samples

Nota de análisis

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Nota al pie de página

To see an example of a Certificate of Analysis for this material enter LRAB3692 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Productos recomendados

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Información de seguridad

• Pictogramas: GHS08,GHS07
• Palabra de señalización: Danger
• Frases de peligro: H302,H340,H350,H360FD
• Consejos de prudencia: P202 - P264 - P270 - P280 - P301 + P312 - P308 + P313
• Clasificaciones de peligro: Acute Tox. 4 Oral - Carc. 1B - Muta. 1B - Repr. 1B
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable