PHR1035

Folic acid

Pharmaceutical Secondary Standard; Certified Reference Material

• Sinónimos: N-[4-[[(2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid, PteGlu, Pteroyl-L-glutamic acid, Vitamin M
• Fórmula empírica (notación de Hill): C₁₉H₁₉N₇O₆
• Número de CAS: 59-30-3
• Peso molecular: 441.40
• Beilstein: 100781
• Número CE: 200-419-0
• Número MDL: MFCD00079305
• Código UNSPSC: 41116107
• eCl@ss: 34058014
• ID de la sustancia en PubChem: 329823065
• NACRES: NA.24

Propiedades

• grado: certified reference material; pharmaceutical secondary standard
• Nivel de calidad: 300
• Agency: traceable to Ph. Eur. F0300000; traceable to USP 1286005
• familia API: folic acid
• CofA: current certificate can be downloaded
• técnicas: HPLC: suitable; gas chromatography (GC): suitable
• aplicaciones: pharmaceutical (small molecule)
• Formato: neat
• temp. de almacenamiento: 2-30°C
• cadena SMILES: NC(N1)=NC(C2=C1N=CC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)=O
• InChI: 1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1
• Clave InChI: OVBPIULPVIDEAO-LBPRGKRZSA-N

Descripción

Descripción general

Folic acid is mostly obtained from the diet itself or from pharmaceutical drugs such as vitamin pills.† It is highly necessary to consume folic acid for the prevention of neural tube defects, mainly anencephaly and spina bifida.† It belongs to the class of water soluble B vitamins called folates.[1] It is mainly used to fortify cereals/grains and dietary supplements.[1]

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Aplicación

Folic acid may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using ultraviolet spectrophotometric technique[2] and microemulsion electrokinetic chromatography.[3]

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Nota de análisis

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Otras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota al pie de página

To see an example of a Certificate of Analysis for this material enter LRAB7352 in the slot below. This is an example certificate only and may not be the lot that you receive.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable