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Merck

B5887

Sigma-Aldrich

Sodium butyrate

≥98.5% (GC)

Sinónimos:

Butyric acid sodium salt

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250 MG
79,20 €
1 G
235,00 €
5 G
971,00 €

79,20 €


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250 MG
79,20 €
1 G
235,00 €
5 G
971,00 €

About This Item

Fórmula lineal:
CH3CH2CH2COONa
Número de CAS:
Peso molecular:
110.09
Beilstein:
3629439
Número CE:
Número MDL:
Código UNSPSC:
12352107
ID de la sustancia en PubChem:
NACRES:
NA.25

79,20 €


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origen biológico

synthetic (organic)

Nivel de calidad

Ensayo

≥98.5% (GC)

Formulario

powder

condiciones de almacenamiento

(Tightly closed. Dry.
Keep in a dry place. )

técnicas

DNA amplification: suitable
cell based assay: suitable
inhibition assay: suitable

color

white

mp

250-253 °C (lit.)

solubilidad

water: 100 mg/mL, clear to slightly hazy, colorless

trazas de catión

Na: 19.8-22.0% (anhydrous)

idoneidad

suitable for DNA precipitation

aplicaciones

cell analysis
life science and biopharma
lipidomics

temp. de almacenamiento

room temp

cadena SMILES

[Na+].CCCC([O-])=O

InChI

1S/C4H8O2.Na/c1-2-3-4(5)6;/h2-3H2,1H3,(H,5,6);/q;+1/p-1

Clave InChI

MFBOGIVSZKQAPD-UHFFFAOYSA-M

Información sobre el gen

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Aplicación

Sodium butyrate has been used:
  • as a component in homogenization and immunoprecipitation buffer for HDAC inhibition in fly embryos and insect s2 cells.[1]
  • as histone deacetylase inhibitor in breast cancer cell line MDA-MB-231, analysed by cell viability assay and viral replication assay.[2]
  • to enhance the production of recombinant tissue-plasminogen activator (t-PA) in Chinese hamster ovary (CHO) cells in a bioreactor.[3]

Acciones bioquímicas o fisiológicas

Sodium butyrate is a short-chain fatty acid that inhibits histone deacetylase (HDAC) in the millimolar range.[1][2] Decreases Ca2+ release from intracellular stores. Induces apoptosis in several cell lines. Sodium butyrate induces the production of recombinant protein in Chinese hamster ovary (CHO) cells and other human cell lines. Sodium butyrate affects the proteome and gene expression pathways in the cells. It represses cell cycle related genes and modifies the genes involved in cell metabolism and apoptosis.[3]

Precaución

Hygroscopic

Otras notas

For additional information on our range of Biochemicals, please complete this form.

Pictogramas

Exclamation mark

Palabra de señalización

Warning

Frases de peligro

Clasificaciones de peligro

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves


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Certificados de análisis (COA)

Lot/Batch Number

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Artículos

Naive pluripotent stem cells cultured in vitro using specialized media and inhibitors mimic "ground-state" cells from blastocysts.

Preguntas

1–3 de 3 Preguntas  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 respuesta
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 respuesta
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      ¿Le ha resultado útil?

  3. I would like to know which is the recommended solvent to make dilutions with Sodium butyrate B5887, they are meant for long-term storage.

    1 respuesta
    1. This product is soluble in water at 100 mg/mL. The filter-sterilized solution is stable for up to 2 years at 2-8°C as indicated for the 500mM prepared solution, product TR-1008.

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