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22642

Sigma-Aldrich

Quinine hemisulfate salt monohydrate

tested according to Ph. Eur.

Sinónimos:

Chinini sulfas, Quinine sulfate (2:1) (salt) dihydrate

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About This Item

Fórmula empírica (notación de Hill):
C20H24N2O2 · 0.5H2O4S · H2O
Número de CAS:
207671-44-1
Peso molecular:
391.47
Beilstein:
6113937
Número MDL:
MFCD00150790
Código UNSPSC:
12352210
ID de la sustancia en PubChem:
329752331
NACRES:
NA.25

Agency

USP/NF
tested according to Ph. Eur.

Nivel de calidad

100

mp

~225 °C (dec.) (lit.)

espectro de actividad antibiótica

parasites

Modo de acción

enzyme | inhibits

cadena SMILES

O.O.OS(O)(=O)=O.COc1ccc2nccc([C@@H](O)C3CC4CCN3C[C@@H]4C=C)c2c1.COc5ccc6nccc([C@@H](O)C7CC8CCN7C[C@@H]8C=C)c6c5

InChI

1S/2C20H24N2O2.H2O4S.2H2O/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;;/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);2*1H2/t2*13-,14-,19-,20+;;;/m00.../s1

Clave InChI

ZHNFLHYOFXQIOW-LPYZJUEESA-N

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Aplicación

Quinine hemisulfate salt monohydrate has been used as a tastant for testing the saccharin and quinine consumption in wild-type or knock-in mice. It has been used for studying the toxicity of heme (FP)-complexes.

Acciones bioquímicas o fisiológicas

Potassium channel blocker. Antimalarial, anticholinergic, antihypertensive, and hypoglycemic agent; alkaloid originally isolated from the Cinchona family of South American trees. Inhibits mitochondrial ATP-regulated potassium channel. Used to study the metabolism of biocrystalized heme, hemozoin, in malarial parasites and to study the toxicity of heme (FP)-complexes.
Quinine hemisulfate is an alkaloid originally isolated from the Cinchona family of South American trees. It inhibits mitochondrial ATP-regulated potassium channel and posssess antimalarial, anticholinergic, antihypertensive and hypoglycemic properties.

Pictogramas

Exclamation mark
GHS07

Palabra de señalización

Warning

Frases de peligro

H315,H319,H335

Clasificaciones de peligro

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órganos de actuación

Respiratory system

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
BCCL4999
BCCH7202
BCCF0803
BCCD6235
BCCC2345

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Jimena A Ballestero et al.
Molecular pharmacology, 68(3), 822-829 (2005-06-16)
In this study, we report the effects of the quinoline derivatives quinine, its optical isomer quinidine, and chloroquine on alpha9alpha10-containing nicotinic acetylcholine receptors (nAChRs). The compounds blocked acetylcholine (ACh)-evoked responses in alpha9alpha10-injected Xenopus laevis oocytes in a concentration-dependent manner, with
P Bednarczyk et al.
The Journal of membrane biology, 199(2), 63-72 (2004-09-24)
The mitochondrial ATP-regulated potassium (mitoK(ATP) channel has been suggested as trigger and effector in myocardial ischemic preconditioning. However, molecular and pharmacological properties of the mitoK(ATP) channel remain unclear. In the present study, single-channel activity was measured after reconstitution of the
Y A Blednov et al.
The Journal of pharmacology and experimental therapeutics, 336(1), 145-154 (2010-09-30)
GABA type A receptors (GABA(A)-Rs) are potential targets of ethanol. However, there are multiple subtypes of this receptor, and, thus far, individual subunits have not been definitively linked with specific ethanol behavioral actions. Interestingly, though, a chromosomal cluster of four
Joe Briscoe et al.
Angewandte Chemie (International ed. in English), 54(15), 4463-4468 (2015-02-24)
New hybrid materials consisting of ZnO nanorods sensitized with three different biomass-derived carbon quantum dots (CQDs) were synthesized, characterized, and used for the first time to build solid-state nanostructured solar cells. The performance of the devices was dependent on the
J P Mooney et al.
Mucosal immunology, 7(6), 1302-1311 (2014-03-29)
Coinfection can markedly alter the response to a pathogen, thereby changing its clinical presentation. For example, non-typhoidal Salmonella (NTS) serotypes are associated with gastroenteritis in immunocompetent individuals. In contrast, individuals with severe pediatric malaria can develop bacteremic infections with NTS
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