IL029
Interleukin-12 Protein, Recombinant human
The recombinant human Interleukin-12 protein (or IL-12 protein) is a potent regulator of cell mediated immune responses & it induces IFN-gamma production by NK & T cells.
Sinónimos:
IL-12
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About This Item
Código UNSPSC:
12352202
eCl@ss:
32160405
NACRES:
NA.77
Productos recomendados
origen biológico
human
Nivel de calidad
recombinante
expressed in CHO cells
Análisis
>98% (SDS-PAGE and HPLC)
actividad específica
≥1.0 x 10E6 U/mg
fabricante / nombre comercial
Chemicon®
técnicas
cell culture | mammalian: suitable
impurezas
<0.1 ng/μg endotoxin (of IL-12; 1EU/μg)
entrada
sample type hematopoietic stem cell(s)
Condiciones de envío
dry ice
Categorías relacionadas
Descripción general
Interleukin-12 (IL-12) is a potent regulator of cell mediated immune responses and it induces IFN-gamma production by NK and T cells. It is produced by activated monocytes/macrophage cells, B lymphocytes, and connective tissue type mast cells. Among its biological activities, IL-12 promotes the growth and activity of activated NK, CD4+ and CD8+ cells and induces the development of IFN-gamma producing Th1 cells. Human IL-12 is a disulfide linked heterodimeric protein with a molecular weight of 75 kDa comprised of disulfide-bonded 35 kDa (p35) and 40 kDa (p40) subunits.
Product Source: CHO cells (Chinese Hamster Ovarian cells)
Aplicación
For most in vitro applications, IL-12 exerts its biological activity in the concentration range of 1.0 to 10.0 ng/mL.
Acciones bioquímicas o fisiológicas
The ED50 as determined by the induction of IFN-g production from NK cells co-stimulated with IL-18 was ≤ 1.0 ng/mL
Forma física
The sterile filtered solution was lyophilized from 0.5X PBS pH 7.2
Almacenamiento y estabilidad
The lyophilized IL-12, though stable at room temperature, is best stored desiccated below 0°C. Reconstitute with sterile water to a concentration of 0.2 mg/mL. Reconstituted IL-12 should be stored in undiluted aliquots at -20°C for up to 6 months.
Información legal
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Certificados de análisis (COA)
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Jiyun Kim et al.
Biomicrofluidics, 9(4), 044109-044109 (2015-09-05)
Fabrication methods for the development of multiplexed immunoassay platforms primarily depend on the individual functionalization of reaction chambers to achieve a heterogeneous reacting substrate composition, which increases the overall manufacturing time and cost. Here, we describe a new type of
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