ABS190

Anti-PIP5K-Type 1 gamma Antibody

from rabbit

• Sinónimos: Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma, PIP5K1-gamma, PtdIns(4)P-5-kinase 1 gamma, Phosphatidylinositol 4-phosphate 5-kinase type I gamma, PIP5KIgamma
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• forma del anticuerpo: purified antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• reactividad de especies: rat, mouse
• técnicas: immunohistochemistry: suitable; western blot: suitable
• isotipo: IgG1
• Nº de acceso NCBI: NP_001140159
• Nº de acceso UniProt: O70161
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: mouse ... Pip5K1C(18717)

Descripción

Descripción general

Phosphatidylinositol-4-phosphate 5-kinase 1 gamma (PIP5K type 1 gamma; PIP5K1γ) is a ubiquitous protein which is enriched in focal adhesion plaques. It is expressed in relatively high levels in the brain, particularly at synaptic sites. PIP5K type 1 gamma is activated by talin, and in turn phosphorylates phosphatidylinositol 4-phosphate to form phosphatidylinositol 4,5-bisphosphate, the precursor to the second messenger phosphatidylinositol 3,4,5-trisphosphate. It indirectly influences vesicle transport, cell adhesion, and cell migration, among other processes. Defects in PIP5K type 1 gamma may contribute to lethal congenital arthrogryposis.

Inmunógeno

recombinant protein corresponding to mouse PIP5K-type 1 gamma.

Aplicación

Anti-PIP5K-Type 1 gamma Antibody detects level of PIP5K-Type 1 gamma & has been published & validated for use in Western Blotting & IHC.

Immunohistochemistry Analysis: A representative lot from an independent laboratory detected PIP5K-Type 1 gamma in rat brain tissues (Wenk, M. R., et al. 2001. Neuron. 32(1):79-88.).

Research Category
Signaling

Research Sub Category
Cytoskeletal Signaling

Calidad

Evaluated by Western Blot in mouse brain tissue lysate.

Western Blot Analysis: 1 mg/mL of this antibody detected PIP5K-Type 1 gamma in 10 mg of mouse brain tissue lysate.

Descripción de destino

~90 kDa observed. The calculated molecular weight of PIP5K Type-1 gamma is 69-72 kDa, but has been observed at ~90 kDa in Western Blot (Volpicelli-Daley, L.A., et al. (2010). 285(37):28708-28714.).

Forma física

Format: Purified

Protein A purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Almacenamiento y estabilidad

Stable for 1 year at 2-8°C from date of receipt.

Nota de análisis

Control
Mouse brain tissue lysate

Otras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable