ABD104

Anti-SnoN Antibody

from rabbit, purified by affinity chromatography

• Sinónimos: Ski-like protein, Ski-related oncogene, Ski-related protein, SnoN
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.75

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• purificado por: affinity chromatography
• reactividad de especies: human
• técnicas: immunocytochemistry: suitable; immunohistochemistry: suitable; western blot: suitable
• Nº de acceso NCBI: NP_005405
• Nº de acceso UniProt: P12757
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... SKIL(6498)

Descripción

Descripción general

The Ski family of oncogenes includes Ski and Sno (Ski-related novel gene, or Ski-like). Ski family members are nuclear proteins that form homodimers and heterodimers, bind to DNA and function as transcriptional activators and repressors. The Ski proteins regulate TGFß induced gene-specific transcriptional activation by effectively repressing Smad activity and, thereby, inhibit TGFß induced cell growth and extracellular matrix production. Recently, SnoN has been shown to maintain pluripotency through selective repression of mesendodermal genes in human ES cells.

Inmunógeno

KLH-conjugated linear peptide corresponding to amino acids 358-372 of human SnoN protein.

Aplicación

Immunohistochemical Analysis: A 1:50 dilution of this antibody detected SnoN in human skeletal muscle myocytes. Immunohistochemical Analysis: A 1:50 dilution of this antibody detected SnoN in human lung tissue.
Immunocytochemicaly Analysis: A 1:100 dilution of this antibody detected SnoN in H9 human embryonic stem cells.

Research Category
Stem Cell Research

Research Sub Category
Pluripotent & Early Differentiation

This Anti-SnoN Antibody is validated for use in Western Blotting and Immunocytochemistry and Immunohistochemistry for the detection of SnoN.

Calidad

Evaluated by Western Blot in a human placenta tissue lysate. Western Blot Analysis: 1 μg/ml of this antibody detected SnoN in a 10μg of human placenta tissue lysate.

Descripción de destino

~80 kDa observed

Forma física

Antigen Affinity Purified

Purified rabbit Polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Almacenamiento y estabilidad

Stable for 1 year at 2-8°C from date of receipt.

Otras notas

Concentration: Please refer to lot specific datasheet.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 1