AB5977

Anti-Musashi-1 Antibody

Chemicon^®, from rabbit

• Sinónimos: Musashi homolog 1
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• forma del anticuerpo: affinity purified immunoglobulin
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• purificado por: affinity chromatography
• reactividad de especies: rodent, mouse, rat, human
• fabricante / nombre comercial: Chemicon^®
• técnicas: immunocytochemistry: suitable; immunohistochemistry: suitable; western blot: suitable
• Nº de acceso NCBI: NM_002442.2
• Nº de acceso UniProt: O43347
• Condiciones de envío: dry ice
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... MSI1(4440)

Descripción

Descripción general

In mammals, the Musashi family is important for cell fate determination, playing roles in maintenance of the stem-cell state, differentiation and tumorigenesis. Musashi1 (also known as Msi1), is selectivley expressed in neural progenitor cells, including neural stem cells. Outside the nervous system, Musashi1 is a selective marker for intestinal stem or early lineage cells. Musashi1 interacts with the Notch pathway during asymmetric cell division by binding the 3′ UTR of Numb. Numb is prevented from repressing Notch signaling when Musashi1 is present.

Especificidad

Reactivity with other species has not been confirmed.

Recognizes Musashi-1.

Inmunógeno

Synthetic peptide, amino acids 5-21 of Musashi.

Aplicación

Detect Musashi-1 using this Anti-Musashi-1 Antibody validated for use in IC, IH & WB.

Immunohistochemistry:
1:200-1:1,000 dilution from a previous lot was used.

Immunocytochemistry:
1:200-1:1,000 dilution from a previous lot was used.

Western blot:
1:200-1:1,000 using ECL.

Optimal working dilutions must be determined by the end user.

Research Category
Neuroscience

Research Sub Category
Neuronal & Glial Markers

Developmental Neuroscience

RNA Binding Protein (RBP)

Calidad

Routinely evaluated by Western Blot on Human Placenta lysates.

Western Blot Analysis:
1:1000 dilution of this lot detected Musashi-1 on 10 μg of Human placenta lysates.

Descripción de destino

39 kDa

Ligadura / enlace

Replaces: 03-114; 04-1041

Forma física

ImmunoAffinity Purified

Purified rabbit polyclonal in buffer containing a solution of 50% saturated ammonium sulfate and PBS containing no preservatives.

Almacenamiento y estabilidad

Stable for 1 year at -80ºC from date of receipt.

Nota de análisis

Control
Mouse cortical neural stem cells (Catalog No. SCR029).

Información legal

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable