8.51200

DOTA-tris(tert-butyl ester)

Novabiochem^®

• Sinónimos: DOTA-tris(tert-butyl ester), Tri-tert-butyl 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate
• Fórmula empírica (notación de Hill): C₂₈H₅₂N₄O₈
• Número de CAS: 137076-54-1
• Peso molecular: 572.73
• Número MDL: MFCD02259697
• Código UNSPSC: 12352108

Propiedades

• Nivel de calidad: 200
• Línea del producto: Novabiochem^®
• formulario: powder
• idoneidad de la reacción: reagent type: fluorescent-labelling reagent
• fabricante / nombre comercial: Novabiochem^®
• mp: 88-93 °C
• aplicaciones: peptide synthesis
• temp. de almacenamiento: 2-8°C
• InChI: 1S/C28H52N4O8/c1-26(2,3)38-23(35)19-30-12-10-29(18-22(33)34)11-13-31(20-24(36)39-27(4,5)6)15-17-32(16-14-30)21-25(37)40-28(7,8)9/h10-21H2,1-9H3,(H,33,34)
• Clave InChI: RVUXZXMKYMSWOM-UHFFFAOYSA-N

Descripción

Descripción general

The most convenient reagent for the labeling of a peptide with DOTA ^[1]. This reagent has good solubility in DMF and DCM, and its free carboxyl group can be easily activated using uronium or phosphonium coupling reagents, enabling it to be attached to peptide amino groups. Removal of the t-butyl ester groups from the DOTA occurs during the course of the TFA-mediated cleavage reaction. The progress of the reaction should be monitored as the cleavage of these esters is slow, owing to the proximity of the basic ring nitrogens.

Literature references

^[1] L. M. De León-Rodrýguez & Z. Kovacs (2008) Bioconjugate Chem, 19, 391.

Nota de análisis

Colour (visual): white to grey
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (NMR): ≥ 95.0 %
Identity (NMR): passes test
NMR-spectrum: passes test

Información legal

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°C): Not applicable