691550-M

Zinc (II) Protoporphyrin IX

A potent and selective inhibitor of heme oxygenase, the enzyme which generates carbon monoxide (CO) and biliverdin.

• Sinónimos: Zinc (II) Protoporphyrin IX, ZnPP-9
• Fórmula empírica (notación de Hill): C₃₄H₃₂N₄O₄Zn
• Número de CAS: 15442-64-5
• Peso molecular: 626.03
• Número MDL: MFCD00011612
• Código UNSPSC: 12171500
• NACRES: NA.22

Propiedades

• Nivel de calidad: 100
• Análisis: ≥95% (TLC)
• formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: dark red
• solubilidad: DMF: soluble; pyridine: soluble
• temp. de almacenamiento: −20°C
• InChI: 1S/C34H34N4O4.Zn/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);/q;+2/p-2/b25-13?,26-13-,27-14?,28-15-,29-14-,30-15?,31-16-,32-16?;
• Clave InChI: FUTVBRXUIKZACV-RGUWPKJZSA-L

Descripción

Descripción general

A potent and selective inhibitor of heme oxygenase, the enzyme which generates carbon monoxide (CO) and biliverdin. Inhibits soluble guanylyl cyclase and produces a time- and concentration-dependent inactivation of all three isoforms of nitric oxide synthase (IC₅₀ = 800 nM, 4 µM, and 5 µM for nNOS, iNOS, and eNOS, respectively). Inhibits relaxation induced by acetylcholine, ANP, and VIP in isolated rat aorta. Blocks interleukin-1 and prevents induction of long-term potentiation. Also useful as an indicator of iron-deficient erythropoiesis. Does not cross the blood-brain barrier.

A potent and selective inhibitor of heme oxygenase, the enzyme which generates carbon monoxide (CO) and biliverdin. Inhibits soluble guanylyl cyclase. Produces a time- and concentration-dependent inactivation of all three isoforms of nitric oxide synthase (IC₅₀ = 0.8 µM, 4.0 µM, and 5.0 µM for nNOS, iNOS, and eNOS, respectively). Inhibits relaxation induced by acetylcholine, ANP, and VIP in isolated rat aorta. Blocks interleukin-1 and prevents induction of long-term potentiation. Also useful as an indicator of iron deficient erythropoiesis. Does not cross the blood-brain barrier.

Acciones bioquímicas o fisiológicas

Primary Target
heme oxygenase

Target IC₅₀: 800 nM, 4 µM, and 5 µM for nNOS, iNOS, and eNOS, respectively

Advertencia

Toxicity: Standard Handling (A)

Otras notas

Wolff, D.J., et al. 1996. Arch. Biochem. Biophys.333, 27.
Bing, O., et al. 1995. NeuroReport 6, 1369.
Hinchliffe, R.F., et al. 1995. Pediatr. Hematol. Oncol. 12, 455.
Kadoya, C., et al. 1995. Stroke 26, 1035.
Ny, L., et al. 1995. Br. J. Pharmacol. 115, 186.
Luo, D., and Vincent, S.R. 1994. Eur. J. Pharmacol. 267, 263.
Marks, G.S., et al. 1993. Can. J. Physiol. Pharmacol. 71, 753.
Zhuo, M., et al. 1993. Science 260, 1946.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable