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282820

Sigma-Aldrich

Protoporphyrin IX zinc(II)

guanylate cyclase inhibitor

Sinónimos:

3,7,12,17-Tetramethyl-8,13-divinyl-2,18-porphinedipropionic acid, 8,13-Divinyl-3,7,12,17-tetramethyl-21H,23H-porphine-2,18-dipropionic acid zinc derivative, Protoporphyrin IX zinc(II) complex

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About This Item

Fórmula empírica (notación de Hill):
C34H32N4O4Zn
Número de CAS:
15442-64-5
Peso molecular:
626.03
Número CE:
239-455-7
Número MDL:
MFCD00011612
Código UNSPSC:
12171500
ID de la sustancia en PubChem:
24857074
NACRES:
NA.47

Nivel de calidad

100

Análisis

≥92% (HPLC)

formulario

powder

color

red to very dark red

λmáx.

426 nm

ε (coeficiente de extinción)

≥10000 at 585-591 nm in pyridine
≥12000 at 548-554 nm in pyridine
≥135000 at 423-429 nm in pyridine

aplicaciones

diagnostic assay manufacturing
hematology
histology

temp. de almacenamiento

room temp

cadena SMILES

Cc1c(CCC(O)=O)c2cc3c(CCC(O)=O)c(C)c4cc5nc(cc6c(C)c(C=C)c(cc1n2)n6[Zn]n34)c(C=C)c5C

InChI

1S/C34H34N4O4.Zn/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);/q;+2/p-2/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;

Clave InChI

FUTVBRXUIKZACV-RGGAHWMASA-L

Descripción general

Protoporphyrin IX zinc(II) (ZnPP) is an anti-oxidant enzyme heme oxygenase-1.

Aplicación

Cellular melanin content in normal human melanocytes treated with ZnPP has been studied. 1 It was used as a standard in a study where the excess formation of ZnPP in iron deficient erythropoiesis was determined by haematofluorometer.
Inhibits soluble guanylate cyclase.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
MKCQ4038
MKCL3047
MKCH9486
MKBV8659V
MKBR4657V

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Diagnostic utility of zinc protoporphyrin to detect iron deficiency in Kenyan pregnant women
Mwangi M, et al.
BMC Medicine, 12(1), 1-1 (2014)
Sha Huang et al.
Translational lung cancer research, 9(6), 2337-2355 (2021-01-26)
The therapeutic efficacy of cisplatin-based chemotherapy for non-small cell lung cancer (NSCLC) is limited by drug resistance. In NSCLC, hyperactivation of nuclear factor erythroid 2-related factor 2 (Nrf2) counteracts oxidative stress to promote chemoresistance. Metformin-mediated downregulation of Nrf2 plays a
Marcio Jose Ferreira et al.
Toxicon : official journal of the International Society on Toxinology, 87, 54-67 (2014-06-03)
Here we evaluated whether Natterins affect the leukocyte-endothelial cell interaction, hampering leukocyte mobilization and extravasation. Leukocyte-endothelial cell interactions were evaluated in venules of mouse cremaster muscle using intravital microscopy. We reported that low doses of Natterins interfere with the cell
Ying Feng et al.
Biochemical and biophysical research communications, 456(2), 549-554 (2014-09-30)
Hyperoxic acute lung injury (HALI) is a clinical syndrome as a result of prolonged supplement of high concentrations of oxygen. Previous studies have shown hyperbaric oxygen preconditioning (HBO-PC) had a protective effect on oxidative injury. In the present study, we
Shiliu Tian et al.
The Journal of pharmacology and experimental therapeutics, 350(1), 5-13 (2014-04-18)
This study aims to investigate the effects of ramipril (RPL) on endothelial dysfunction associated with diabetes mellitus using cultured human aortic endothelial cells (HAECs) and a type 2 diabetic animal model. The effect of RPL on vasodilatory function in fat-fed
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