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Sigma-Aldrich

Ro-20-1724

≥98% (TLC), solid, cAMP phosphodiesterase inhibitor, Calbiochem

Sinónimos:

Ro-20-1724, 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone

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About This Item

Fórmula empírica (notación de Hill):
C15H22N2O3
Número de CAS:
29925-17-5
Peso molecular:
278.35
Número MDL:
MFCD00077397
Código UNSPSC:
12352200
NACRES:
NA.77

product name

Ro-20-1724, A cell-permeable, selective inhibitor of cAMP-specific phosphodiesterase (PDE IV; IC₅₀ = 2 µM).

Nivel de calidad

100

Análisis

≥98% (TLC)

formulario

solid

fabricante / nombre comercial

Calbiochem®

condiciones de almacenamiento

OK to freeze

color

white

solubilidad

DMSO: 20%
ethanol: 4%

Condiciones de envío

ambient

temp. de almacenamiento

10-30°C

InChI

1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18)

Clave InChI

PDMUULPVBYQBBK-UHFFFAOYSA-N

Descripción general

A cell-permeable, selective inhibitor of cAMP-specific phosphodiesterase (PDE IV; IC50 = 2 µM). Inhibits superoxide generation and arachidonic-induced platelet aggregation. Also inhibits fMLP-induced neutrophil adhesion to vascular endothelial cells.
Selective inhibitor of cAMP-specific phosphodiesterase (PDE IV, IC50 = 2 µM). Inhibits superoxide generation and arachidonic-induced platelet aggregation. Also inhibits fMLP-induced neutrophil adhesion to vascular endothelial cells.

Acciones bioquímicas o fisiológicas

Cell permeable: yes
Primary Target
PDE IV
Product does not compete with ATP.
Reversible: no
Target IC50: 2 µM against PDE IV

Advertencia

Toxicity: Irritant (B)

Otras notas

Derian, C.K., et al. 1995. J. Immunol. 154, 308.
Rubin, L.L., et al. 1991. J. Cell Biol.115, 1725.
Lad, P.M., et al. 1985. Biochim. Biophys. Acta 846, 286.
Bergstrand, H., et al. 1977. Mol. Pharmacol.13, 38.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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