524748

PDE4D Inhibitor, GEBR-7b

The PDE4D Inhibitor, GEBR-7b controls the biological activity of PDE4D. This small molecule/inhibitor is primarily used for Cell Signaling applications.

• Sinónimos: PDE4D Inhibitor, GEBR-7b, GEBR-7b, (E)-3-(cyclopentyloxy)-4-methoxybenzaldehyde, O-2-(2,6-dimethylmorpholino)-2-oxoethyl oxime
• Fórmula empírica (notación de Hill): C₂₁H₃₀N₂O₅
• Número de CAS: 1349848-90-3
• Peso molecular: 390.47
• Número MDL: MFCD28053503
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥95% (HPLC)
• Formulario: semisolid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: pale yellow
• solubilidad: DMSO: 100 mg/mL, clear, colorless
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• cadena SMILES: COC1=C(OC2CCCC2)C=C(/C([H])=N/OCC(N3CC(C)OC(C)C3)=O)C=C1
• Clave InChI: JEXHQZPMUKFOIV-SSDVNMTOSA-N

Descripción

Descripción general

A cell permeable, potent, and selective oxime PDE4D inhibitor (IC₅₀ = 0.67 µM) which displays much reduced activities toward other PDE4 isoforms. It is shown to cause a significant 40% increase in extracellular cAMP in the hippocampus of freely moving rats in vivo at 100 µM, but has no effect on Aβ levels. This compound elicits cognitive enhancement in vivo at the optimum dose of 0.003 mg/kg in both mice and rat models, and unlike rolipram, does not cause emesis-like behavior in rodents.

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Otras notas

Bruno, O., et al. 2011. Br. J. Pharmacol.in press.
Bruno, O., et al. 2009. J. Med. Chem.52, 6546.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable