487929-M

Nocodazole

InSolution, ≥97%, 50 mM in DMSO, Inhibitor of mammalian cell mitosis via a highly aspecific antimicrotubular activity

• Sinónimos: InSolution Nocodazole, Methyl-(5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl)-carbamate, Methyl-5-(thiophene-2-carbonyl)-1H-benzo[d]imidazol-2-ylcarbamate, R17934, R17934, Methyl-(5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl)-carbamate, Methyl-5-(thiophene-2-carbonyl)-1H-benzo[d]imidazol-2-ylcarbamate
• Fórmula empírica (notación de Hill): C₁₄H₁₁N₃O₃S
• Número de CAS: 31430-18-9
• Peso molecular: 301.32
• Número MDL: MFCD00005588
• Código UNSPSC: 12352200

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥97% (HPLC)
• Formulario: liquid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; avoid repeated freeze/thaw cycles; desiccated (hygroscopic); protect from light
• temp. de almacenamiento: −70°C
• cadena SMILES: [s]1c(ccc1)C(=O)c2cc3nc([nH]c3cc2)NC(=O)OC
• InChI: 1S/C14H11N3O3S/c1-20-14(19)17-13-15-9-5-4-8(7-10(9)16-13)12(18)11-3-2-6-21-11/h2-7H,1H3,(H2,15,16,17,19)
• Clave InChI: KYRVNWMVYQXFEU-UHFFFAOYSA-N

Descripción

Descripción general

Inhibitor of mitosis. Has highly specific antimicrotubular activity for mammalian cells in culture. Promotes tubulin depolymerization. Also acts as a high-affinity ligand for the cancer-related kinases ABL, c-KIT, BRAF, and MEK (K_d<2 M). The solid form of this compound (Cat. No. 487928) is also available.

Acciones bioquímicas o fisiológicas

Primary Target
Microtubules

Secondary Target
Certain kinases

Advertencia

Toxicity: Irritant (B)

Forma física

A 50 mM (10 mg/664 µL) solution of Nocodazole (Cat. No. 487928) in DMSO.

Reconstitución

Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 1 year at -70°C.

Otras notas

Park, H., et al. 2012. Chem. Med. Chem.7, 53.
Bunz, F., et al. 1998. Science282, 1497.
Fleischman, L.F., et al. 1993. Oncogene8, 771.Pomies, P., and Block, M.R. 1992. Biochem. Biophys. Res. Commun.189, 1429.
Rennison, M.E., et al. 1992. J. Cell Sci.102, 239.
Thyberg, J., and Moskalewski, S. 1992. J. Cell Sci.103, 1167.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Pictogramas: GHS08
• Palabra de señalización: Warning
• Frases de peligro: H341
• Consejos de prudencia: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Clasificaciones de peligro: Muta. 2
• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): 188.6 °F - closed cup - (refers to pure substance)
• Punto de inflamabilidad (°C): 87 °C - closed cup - (refers to pure substance)