344085

Folimycin, Streptomyces sp.

A highly sensitive and specific inhibitor of vacuolar-type H⁺-ATPase (V-type; K_i = 20 pM).

• Sinónimos: Folimycin, Streptomyces sp., Concanamycin A
• Fórmula empírica (notación de Hill): C₄₆H₇₅NO₁₄
• Número CAS: 80890-47-7
• Peso molecular: 866.09
• UNSPSC Code: 12352200
• MDL number: MFCD00210037
• Assay: ≥90% (HPLC)
• Form: lyophilized solid
• Storage condition: OK to freeze, protect from light

Propiedades

• Quality Segment: 100
• assay: ≥90% (HPLC)
• form: lyophilized solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• solubility: DMSO: soluble
• shipped in: ambient
• storage temp.: −20°C
• InChI: 1S/C46H75NO14/c1-13-16-34-28(7)37(58-38-22-33(48)43(31(10)57-38)60-45(47)53)23-46(54,61-34)30(9)41(51)29(8)42-35(55-11)18-15-17-24(3)19-26(5)39(49)32(14-2)40(50)27(6)20-25(4)21-36(56-12)44(52)59-42/h13,15-18,20-21,26-35,37-43,48-51,54H,14,19,22-23H2,1-12H3,(H2,47,53)/b16-13+,18-15+,24-17+,25-20+,36-21-/t26-,27-,28-,29+,30+,31-,32+,33-,34-,35+,37-,38+,39+,40-,41-,42-,43-,46-/m1/s1
• InChI key: DJZCTUVALDDONK-HQMSUKCRSA-N

Descripción

General description

A highly sensitive and specific inhibitor of vacuolar-type H⁺-ATPase (V-type; K_i = 20 pM). Inhibits acidification of organelles, such as lysosomes and the Golgi apparatus. Also blocks cell surface expression of viral envelope glycoproteins without affecting their synthesis. Useful for studies of intracellular protein translocation. Exhibits cytotoxic effects on a number of cell lines in a cell viability assay.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Vacuolar-type H+-ATPase

Product does not compete with ATP.

Reversible: no

Target K_i: 20 pM against vacuolar-type H+-ATPase

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.

Further dilute with aqueous buffers just prior to use.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Kane, M.D., et al. 1999. J. Neurochem.72, 1939.
Nishihara, T., et al. 1995. Biochem. Biophys. Res. Commun.212, 255.
Muroi, M., et al. 1994. Biosci. Biotech. Biochem.58, 425.
Drose, S., et al. 1993. Biochemistry32, 3902.
Muroi, M., et al. 1993. Biochem. Biophys. Res. Commun.193, 999.
Muroi, M., et al. 1993. Cell Struct. Funct.18, 139.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Highly Toxic (H)

Información de seguridad

• pictograms: GHS06
• signalword: Danger
• hcodes: H300 + H310 + H330,H319
• pcodes: P260 - P262 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Eye Irrit. 2
• Clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable