343020

Flt-3 Inhibitor

The Flt-3 Inhibitor, also referenced under CAS 301305-73-7, controls the biological activity of Flt-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Sinónimos: Flt-3 Inhibitor
• Fórmula empírica (notación de Hill): C₁₈H₂₀N₂O₄S
• Número de CAS: 301305-73-7
• Peso molecular: 360.43
• Número MDL: MFCD00617269
• Código UNSPSC: 12352106
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: white
• solubilidad: DMSO: <4 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: 2-8°C
• cadena SMILES: [s]1c2c(c(c1NC(=O)c3cc(c(cc3)OC)OC)C(=O)N)CCCC2
• InChI: 1S/C18H20N2O4S/c1-23-12-8-7-10(9-13(12)24-2)17(22)20-18-15(16(19)21)11-5-3-4-6-14(11)25-18/h7-9H,3-6H2,1-2H3,(H2,19,21)(H,20,22)
• Clave InChI: FSPQCTGGIANIJZ-UHFFFAOYSA-N

Descripción

Descripción general

A cell-permeable thienylcarboxamide compound that acts as a potent, ATP-competitive, and highly selective Flt-3 inhibitor (IC₅₀ = 42 nM) with little effect against a panel of 22 other kinases (IC₅₀ ≥3 µM). Shown to exhibit antiproliferative properties against the human acute myelogenous leukemia cell line MV4-11 (IC₅₀ = 340 nM) expressing constitutively active Flt-3.

Acciones bioquímicas o fisiológicas

Cell permeable: yes

Product competes with ATP.

Reversible: no

Target IC₅₀: 42 nM against Flt-3

Envase

Packaged under inert gas

Advertencia

Toxicity: Irritant (B)

Otras notas

Patch, R.J., et al. 2006. Bioorg. Med. Chem. Lett.16, 3282.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3