251800

Daunorubicin, Hydrochloride

Potent cell-permeable anticancer agent whose potential target site may be mitochondrial cytochrome c oxidase.

• Sinónimos: Daunorubicin, Hydrochloride, Daunomycin, HCl
• Fórmula empírica (notación de Hill): C₂₇H₂₉NO₁₀ · xHCl
• Número de CAS: 23541-50-6
• Peso molecular: 527.52 (free base basis)
• Número MDL: MFCD04974507
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Formulario: crystalline solid
• potencia: ≥840 g/kg
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; desiccated (hygroscopic)
• color: red
• solubilidad: aqueous buffer: soluble; methanol: soluble; water: soluble
• Condiciones de envío: ambient
• temp. de almacenamiento: 10-30°C
• InChI: 1S/C27H29NO10.ClH/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33;/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3;1H/t10-,14-,16-,17-,22+,27-;/m0./s1
• Clave InChI: GUGHGUXZJWAIAS-QQYBVWGSSA-N

Descripción

Descripción general

Potent cell-permeable anticancer agent whose potential target site may be mitochondrial cytochrome c oxidase. Has been shown to inhibit RNA and DNA synthesis. Inhibits eukaryotic topoisomerases I and II. Induces DNA single-strand breaks. Also induces apoptosis in HeLa S3 tumor cells.

Potent cell-permeable anticancer agent whose potential target site may be mitochondrial cytochrome C oxidase. Has been shown to inhibit RNA and DNA synthesis and to intercalate into DNA. Inhibits eukaryotic topoisomerase I and II. Induces DNA single strand breaks. Induces apoptosis in HeLaS3 tumor cells.

Acciones bioquímicas o fisiológicas

Cell permeable: yes

Primary Target
DNA synthesis, RNA synthesis

Product does not compete with ATP.

Reversible: no

Advertencia

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Reconstitución

Following reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 1 month at 4°C.

Otras notas

Friedenberg, W.R., et al. 1995. Am. J. Clin. Oncol. 18, 105.
Papadopoulou, L.C., and Tsiftsoglou, A.S. 1993. Cancer Res. 53, 1072.
Skladanowski, A., and Konopa, J. 1993. Biochem. Pharmacol.46, 375.
Wolff, M., and Jelkmann, W. 1993. Ann. Hematol. 66, 27.
Bellec, F., et al. 1992. Flow Cytometry 13, 880.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Pictogramas: GHS06,GHS08
• Palabra de señalización: Danger
• Frases de peligro: H301,H341,H351,H360FD
• Consejos de prudencia: P202 - P264 - P280 - P301 + P310 - P405 - P501
• Clasificaciones de peligro: Acute Tox. 3 Oral - Carc. 2 - Muta. 2 - Repr. 1B
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3