219372

Cathepsin G Inhibitor I

≥98% (HPLC), solid, cathepsin G inhibitor, Calbiochem^®

• Sinónimos: Cathepsin G Inhibitor I
• Fórmula empírica (notación de Hill): C₃₆H₃₃N₂O₆P
• Número de CAS: 429676-93-7
• Peso molecular: 620.63
• Número MDL: MFCD28137715
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nombre del producto: Cathepsin G Inhibitor I, The Cathepsin G Inhibitor I, also referenced under CAS 429676-93-7, controls the biological activity of Cathepsin G. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: solid
• potencia: 53 nM IC₅₀
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: white
• solubilidad: DMSO: 5 mg/mL; methanol: soluble
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C
• cadena SMILES: [P](=O)(O)(O)C(c5c6c(ccc5)cccc6)C(=O)c1cc2c(cc1C(=O)N(C3CCN(CC3)C(=O)c4ccccc4)C)cccc2
• InChI: 1S/C36H33N2O6P/c1-37(28-18-20-38(21-19-28)35(40)25-11-3-2-4-12-25)36(41)32-23-27-14-6-5-13-26(27)22-31(32)33(39)34(45(42,43)44)30-17-9-15-24-10-7-8-16-29(24)30/h2-17,22-23,28,34H,18-21H2,1H3,(H2,42,43,44)
• Clave InChI: GNOZQRKYZJSIPZ-UHFFFAOYSA-N

Descripción

Descripción general

A potent, selective, reversible, and competitive non-peptide inhibitor of cathepsin G (IC₅₀ = 53 nM and K_i = 63 nM). Weakly inhibits chymotrypsin (K_i = 1.5 µM) and does not have any significant inhibitory effect on thrombin, factor Xa, factor IXa, plasmin, trypsin, tryptase, proteinase 3, and human leukocyte elastase (IC₅₀ >100 µM).

A potent, selective, reversible, competitive, non-peptide inhibitor of cathepsin G [IC₅₀ = 53 nM and K_i = 63 nM]. Weakly inhibits chymotrypsin (K_i = 1.5 µM) and poorly inhibits thrombin, factor Xa, factor IXa, plasmin, trypsin, tryptase, proteinase 3, and human leukocyte elastase (IC₅₀ >100 µM).

Acciones bioquímicas o fisiológicas

Cell permeable: no

Primary Target
cathepsin G

Product does not compete with ATP.

Reversible: yes

Target K_i: 63 nM for cathepsin G

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Otras notas

Greco, M.N., et al. 2002. J. Am. Chem. Soc.124, 3810.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable