GST-tagged fusion protein corresponding to residues 31-233 of human LAT
Aplicación
Anti-LAT Antibody detects level of LAT & has been published & validated for use in IP & WB.
Research Category Inflammation & Immunology
Research Sub Category Immunoglobulins & Immunology
Calidad
routinely evaluated by immunoblot on RIPA lysates from Jurkat cells
Descripción de destino
36/38 kDa
Forma física
Format: Purified
Protein A Purified immunoglobulin in 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, and 0.05% sodium azide.
Protein A purified
Almacenamiento y estabilidad
Stable for 1 year at 2-8°C from date of receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Nota de análisis
Control Positive Antigen Control: Catalog #12-303, Jurkat cell lysate.
Otras notas
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Información legal
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 1
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Assessment of caspase mediated degradation of linker for activation of T cells (LAT) at a single cell level.
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Displacement of linker for activation of T cells from the plasma membrane due to redox balance alterations results in hyporesponsiveness of synovial fluid T lymphocytes in rheumatoid arthritis.
S I Gringhuis, A Leow, E A Papendrecht-Van Der Voort, P H Remans, F C Breedveld, C L Verweij
Journal of immunology (Baltimore, Md. : 1950) (1950)
The Journal of cell biology, 151(2), 199-208 (2000-10-19)
Activation of T cell antigen receptor (TCR) induces tyrosine phosphorylations that mediate the assembly of signaling protein complexes. Moreover, cholesterol-sphingolipid raft membrane domains have been implicated to play a role in TCR signal transduction. Here, we studied the assembly of
Activating and inhibitory mutations in adjacent tyrosines in the kinase domain of ZAP-70.
Wange, R L, et al.
The Journal of Biological Chemistry, 270, 18730-18733 (1995)
The Journal of cell biology, 154(3), 645-658 (2001-08-08)
In mast cells, cross-linking the high-affinity IgE receptor (Fc(epsilon)RI) initiates the Lyn-mediated phosphorylation of receptor ITAMs, forming phospho-ITAM binding sites for Syk. Previous immunogold labeling of membrane sheets showed that resting Fc(epsilon)RI colocalize loosely with Lyn, whereas cross-linked Fc(epsilon)RI redistribute
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