902659

Amino-PEG6-t-butyl ester

• Sinónimos: tert-Butyl 1-amino-3,6,9,12,15,18-hexaoxahenicosan-21-oate, H₂N-PEG6-CH₂CH₂COOtBu
• Fórmula empírica (notación de Hill): C₁₉H₃₉NO₈
• Número de CAS: 1286281-32-0
• Peso molecular: 409.51
• Número MDL: MFCD13184944
• Código UNSPSC: 51171641
• NACRES: NA.22

Propiedades

• Formulario: liquid
• idoneidad de la reacción: reagent type: cross-linking reagent
• índice de refracción: n/D 1.4562
• densidad: 1.06581 g/mL
• grupo funcional: amine; ester
• temp. de almacenamiento: −20°C
• cadena SMILES: NCCOCCOCCOCCOCCOCCOCCC(OC(C)(C)C)=O
• InChI: 1S/C19H39NO8/c1-19(2,3)28-18(21)4-6-22-8-10-24-12-14-26-16-17-27-15-13-25-11-9-23-7-5-20/h4-17,20H2,1-3H3
• Clave InChI: QGSFECNPSLZGGT-UHFFFAOYSA-N

Descripción

Aplicación

This heterobifunctional, PEGylated crosslinker features an amino group at one end and t-butyl-protected carboxyl group at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Amino-PEG6-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

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Información legal

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable