765139

Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide)

PEG average M_n 5,000, PLGA M_n 7,000

• Sinónimos: PEG-PLGA, Polyethylene glycol, mPEG-b-PLGA
• Fórmula lineal: H[(C₃H₄O₂)_x(C₂H₂O₂)_y]_mO[C₂H₄O]_nCH₃
• Código UNSPSC: 12162002
• NACRES: NA.23

Propiedades

• Formulario: solid
• Nivel de calidad: 100
• cociente alimentación: lactide:glycolide 50:50
• mol peso: PEG average M_n 5,000; PLGA M_n 7,000; average M_n 12,000 (total)
• marco temporal de la degradación: 1-4 weeks
• temperatura de transición: T_g 24 °C; T_m 38-43 °C
• PDI: <2.0
• temp. de almacenamiento: 2-8°C

Descripción

Descripción general

Amphiphilic block copolymers (AmBC) are made up of two chemically different homopolymer blocks. One of the block is hydrophilic and the other one is hydrophobic. These macromolecules have the properties to self-assemble when dissolved in an aqueous media. PEG-PLGA is one the most commonly used biodegradable amphiphilic block copolymers for drug delivery applications. PEG is the hydrophilic part and PLGA is the hydrophobic part.[1]

Aplicación

Used in the synthesis of targeted nanoparticles which are used for differential delivery and controlled release of drugs.[2][3]

forming "stealth" pegylated microparticles

Características y beneficios

• Good biocompatibility, low immunogenicity and good degradability.
• Properties can be easily modulated by changing the block copolymer segment sizes to suit a particular application. [1]

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): No data available
• Punto de inflamabilidad (°C): No data available