The ability of closely related platinum group metal salts (PGMS) to cross-react with the principal sensitising agent ammonium hexachloroplatinate IV was investigated in refinery workers. Selected subjects were screened by skin prick test, specific RAST, RAST inhibition, and primate PCA
The American review of respiratory disease, 134(4), 719-725 (1986-10-01)
Three groups of adult male cynomolgus monkeys (Macaca fascicularis) were exposed to either 200 micrograms/m3 ammonium hexachloroplatinate [(NH4)2PtCl6], 200 micrograms (NH4)2PtCl6 concurrently with 1 ppm ozone (O3), or to 1 ppm O3 only. The animals were exposed by inhalation for
Identification of the allergenic potency of chemicals is a key step in the safety assessment process. Predictive assays that require no or few animals are needed. To develop an alternative in vitro mouse bone marrow-derived dendritic cell (BMDC) assay to
Allergy to the complex salts of platinum. A review of the literature and three case reports.
P Orbaek
Scandinavian journal of work, environment & health, 8(2), 141-145 (1982-06-01)
American journal of respiratory and critical care medicine, 160(2), 435-438 (1999-08-03)
The development of sensitization to inhaled allergens is determined by the interaction of multiple genetic and environmental influences. Occupational sensitization to low-molecular-weight chemicals allows a specific immunological response to an inhaled hapten to be studied in a well-defined population with
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