MAPK8
mitogen-activated protein kinase 8
Sinónimos:
JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c
Especie:
Human MAPK8 (5599), Mouse Mapk8 (26419), Rat Mapk8 (116554), chicken MAPK8 (423778), cow MAPK8 (539941), Goat MAPK8 (100861087), domestic cat MAPK8 (101091310), Horse MAPK8 (100051798), dog MAPK8 (477746), Domestic Rabbit MAPK8 (100346929) ...Más
ID UniProtKB:
ID del gen:
- Human(5599) Summary: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jun 2013]
- Mouse(26419) mitogen-activated protein kinase 8
- Rat(116554) mitogen-activated protein kinase 8
- chicken(423778) mitogen-activated protein kinase 8
- cow(539941) mitogen-activated protein kinase 8
- Goat(100861087) mitogen-activated protein kinase 8
- domestic cat(101091310) mitogen-activated protein kinase 8
- Horse(100051798) mitogen-activated protein kinase 8
- dog(477746) mitogen-activated protein kinase 8
- Domestic Rabbit(100346929) mitogen-activated protein kinase 8
- sheep(101116201) mitogen-activated protein kinase 8
- domestic guinea pig(100722333) mitogen-activated protein kinase 8
- naked mole-rat(101715259) mitogen-activated protein kinase 8
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ELISA
Referencia del producto
Descripción
Especie
Cell-Based ELISA for detecting phospho-JNK (pThr183 / pTyr185) in cultured cell lines, 96 assays,
Especie
human
Cell-Based ELISA Sampler Kit for detecting phospho-ERK1/2 (pThr202/pTyr204), phospho-JNK (pThr183/pTyr185), and phospho-p38 MAPK (pThr180/pTyr182) in cultured cell lines, 192 assays,
Especie
rat, human, mouse
Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-phospho-JNK1/2 (pThr183/pTyr185) antibody produced in rabbit, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human, rat
Aplicación
immunocytochemistry
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anticuerpo anti-fosfo-JNK (Thr183/Tyr185, Thr221/Tyr223), from rabbit, purified by affinity chromatography,
Reactividad de especies
xenopus, bovine, canine, chicken, equine, horse, human, mouse, rat
Aplicación
activity assay
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-phospho JNK (Thr183, Tyr185) Antibody, clone 3F7, ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
human, mouse
Aplicación
immunocytochemistry
immunohistochemistry
inhibition assay
western blot
immunohistochemistry
inhibition assay
western blot
PhosphoDetect Anti-SAPK/JNK (pThr¹⁸³, Tyr¹⁸⁵) Rabbit pAb, liquid, Calbiochem®,
Reactividad de especies
caenorhabditis elegans, drosophila, chicken, human, mouse, rat
Aplicación
Anti-SAPK/JNK Rabbit pAb, liquid, Calbiochem®,
Reactividad de especies
human, mouse, rat
Aplicación
Small Molecule - Inhibitor
Proteins
Referencia del producto
Descripción
Especie
JNK1α1/SAPK1c Protein, inactive, 50 g, Unactive, N-terminal His6-tagged recombinant, human, full-length JNK1α1/SAPK1c, for use in Kinase Assays.,
Especie
human
JNK1, active, GST tagged from mouse, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥90% (SDS-PAGE), buffered aqueous glycerol solution,
Especie
mouse
JNK1α1/SAPK1c Protein, active, 10 µg, Active, recombinant full-length human JNK1α1/SAPK1c with an N-terminal His-tag, for use in Kinase Assays.,
Especie
human