I7379

Imipramine hydrochloride

≥99% (TLC), powder, selective serotonin reuptake inhibitor

• Sinónimos: 10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride, 5-[3-(Dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine hydrochloride
• Fórmula empírica (notación de Hill): C₁₉H₂₄N₂ · HCl
• Número de CAS: 113-52-0
• Peso molecular: 316.87
• EC Number: 204-030-7
• MDL number: MFCD00012669
• UNSPSC Code: 12352116
• PubChem Substance ID: 24278097
• NACRES: NA.77

Propiedades

• Nombre del producto: Imipramine hydrochloride, ≥99% (TLC)
• Quality Level: 200
• assay: ≥99% (TLC)
• form: powder
• color: white
• solubility: H₂O: 50 mg/mL
• originator: Novartis
• SMILES string: Cl[H].CN(C)CCCN1c2ccccc2CCc3ccccc13
• InChI: 1S/C19H24N2.ClH/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21;/h3-6,8-11H,7,12-15H2,1-2H3;1H
• InChI key: XZZXIYZZBJDEEP-UHFFFAOYSA-N
• Gene Information: human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR4(3360) , HTR5A(3361) , HTR5B(645694) , HTR6(3362) , HTR7(3363) , SLC6A2(6530) , SLC6A4(6532)

Descripción

General description

Imipramine is a tricyclic antidepressant. It has a half-life of 6 to 20 hours.[1] Imipramine is made up of a tricyclic nucleus, that consists of two phenyl rings and a central cycloheptadien ring.[2]

Application

Imipramine hydrochloride has been used:

• as a non- selective serotonin reuptake inhibitor (SSRI) tricyclic anti-depressant (DD-IMI) to treat animals[3]
• to investigate its interaction with insulin in aqueous solution[4]
• to abolish the ability of internalized lipoproteins to stimulate cholesteryl esterification[5]

Biochem/physiol Actions

Tricyclic antidepressant; inhibits the serotonin and norepinephrine transporters with K_is of 7.7 nM and 67 nM, respectively. Has little effect on the dopamine transporter (K_i = 25 μM).

Tricyclic antidepressant; inhibits the serotonin and norepinephrine transporters; has little effect on the dopamine transporter.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters and Chloride Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• pictograms: GHS06
• signalword: Danger
• hcodes: H300
• pcodes: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 2 Oral
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable