N7261

Nortriptyline hydrochloride

≥98% (HPLC), norepinephrine and serotonin inhibitor, powder

• Sinónimos: 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine hydrochloride, Desmethylamitriptyline hydrochloride
• Fórmula empírica (notación de Hill): C₁₉H₂₁N · HCl
• Número CAS: 894-71-3
• Peso molecular: 299.84
• NACRES: NA.77
• PubChem Substance ID: 24278107
• UNSPSC Code: 41116107
• EC Number: 212-973-0
• MDL number: MFCD00058024
• eCl@ss: 32120505
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• Nombre del producto: Nortriptyline hydrochloride, ≥98% (HPLC), powder
• Quality Segment: 200
• assay: ≥98% (HPLC)
• form: powder
• color: white to off-white
• solubility: ethanol: 100 mg/mL, H₂O: soluble
• originator: Eli Lilly
• SMILES string: Cl.CNCC\C=C1\c2ccccc2CCc3ccccc13
• InChI: 1S/C19H21N.ClH/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19;/h2-5,7-11,20H,6,12-14H2,1H3;1H
• InChI key: SHAYBENGXDALFF-UHFFFAOYSA-N
• Gene Information: human ... HTR2A(3356), HTR2B(3357), HTR2C(3358), SLC6A2(6530), SLC6A4(6532)

Descripción

Biochem/physiol Actions

Tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter (K_i = 3.4 nM) than the serotonin transporter (K_i = 161 nM). 5-HT₂ serotonin receptor antagonist.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Pictogramas: GHS07
• Palabra de advertencia: Warning
• Códigos de peligro: H302
• Indicaciones de precaución: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable
• EPI (equipos de protección individual): dust mask type N95 (US), Eyeshields, Faceshields, Gloves