A7470
Anti-c-Myc
affinity isolated antibody
Sinónimos:
Anti-c-Myc
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.56
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biological source
rabbit
conjugate
agarose conjugate
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human
analyte chemical class(es)
proteins (c-Myc)
technique(s)
affinity chromatography: suitable
immunoprecipitation (IP): suitable
capacity
≥10 nmol/mL binding capacity (c-Myc tagged fusion protein)
≥7 nmol/mL elution capacity (c-Myc tagged fusion protein)
UniProt accession no.
storage temp.
2-8°C
Gene Information
human ... MYC(4609)
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General description
The human c-Myc proto-oncogene belongs to MYC oncogene family and is the human cellular homolog of the avian v-Myc gene found in several leukemogenic retroviruses. c-Myc gene is localized on human chromosome 8q24.21. The two major domains of include the N-terminal box regions and the C-terminal basic-region with helix-loop-helix/leucine-zipper motif.
Specificity
Anti-c-Myc recognizes an epitope located on c-Myc tagged fusion proteins.
Immunogen
péptido sintético de la proteína p62c-Myc humana.
Application
Anti-c-Myc Agarose Affinity Gel antibody produced in rabbit has been used in:
- chromatin immunoprecipitation (ChIP)
- co-immunoprecipitation
- western blotting
- immunofluorescence
- immunoprecipitation
Biochem/physiol Actions
c-Myc proto-oncogene increased expression is observed in a variety of human tumors. Amplification of Myc gene locus is observed in angiosarcomas and translocation is implicated in Burkitt′s lymphoma. c-Myc is a master regulator and targets a wide variety of metabolic events. An epitope located within amino acid residues 410-419 (EQKLISEEDL) of human c-Myc has been widely used as a tag in many expression vectors, enabling the expression of proteins as c-Myc tagged fusion proteins. Anti-c-Myc agarose is useful in the purification of expressed c-Myc tagged fusion proteins in bacterial lysates or transfected cells.
Physical form
Suspension of beaded agarose (1:1 v/v) in 0.01 M phosphate buffered saline containing 15 mM sodium azide.
Storage and Stability
For continuous use and extended storage, store at 2 °C to 8 °C. Do not freeze.
Disclaimer
Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Referencia del producto
Descripción
Precios
Storage Class
11 - Combustible Solids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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