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Q0132

Quinine sulfate

meets USP testing specifications, monograph mol wt. 782.94 ((C20H24N2O2)2 . H2SO4 . 2H2O)

Sinónimos:

Quinine hemisulfate salt monohydrate, Quinine sulfate (2:1) (salt) dihydrate

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About This Item

Fórmula empírica (notación de Hill):
C20H24N2O2 · 0.5H2O4S · H2O
Número de CAS:
207671-44-1
Peso molecular:
391.47
Beilstein/REAXYS Number:
6113937
MDL number:
MFCD00150790
UNSPSC Code:
12352210
PubChem Substance ID:
24899321
NACRES:
NA.21

agency

USP/NF
meets USP testing specifications

mol wt

monograph mol wt. 782.94

mp

~225 °C (dec.) (lit.)

antibiotic activity spectrum

parasites

mode of action

enzyme | inhibits

SMILES string

O.O.OS(O)(=O)=O.COc1ccc2nccc([C@@H](O)C3CC4CCN3C[C@@H]4C=C)c2c1.COc5ccc6nccc([C@@H](O)C7CC8CCN7C[C@@H]8C=C)c6c5

InChI

1S/2C20H24N2O2.H2O4S.2H2O/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;;/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);2*1H2/t2*13-,14-,19-,20+;;;/m00.../s1

InChI key

ZHNFLHYOFXQIOW-LPYZJUEESA-N

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Application

Use to study the metabolism of biocrystalized heme, hemozoin, in malarial parasites, the toxicity of heme (FP)-complexes and to inhibit mitochondrial ATP-regulated potassium channel.

Biochem/physiol Actions

Potassium channel blocker. Antimalarial, anticholinergic, antihypertensive, and hypoglycemic agent; alkaloid originally isolated from the Cinchona family of South American trees. Inhibits mitochondrial ATP-regulated potassium channel. Used to study the metabolism of biocrystalized heme, hemozoin, in malarial parasites and to study the toxicity of heme (FP)-complexes.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
SLCF3150
SLCD5540
SLBX2275
SLBW2571
SLBV1377

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J P Mooney et al.
Mucosal immunology, 7(6), 1302-1311 (2014-03-29)
Coinfection can markedly alter the response to a pathogen, thereby changing its clinical presentation. For example, non-typhoidal Salmonella (NTS) serotypes are associated with gastroenteritis in immunocompetent individuals. In contrast, individuals with severe pediatric malaria can develop bacteremic infections with NTS
Joe Briscoe et al.
Angewandte Chemie (International ed. in English), 54(15), 4463-4468 (2015-02-24)
New hybrid materials consisting of ZnO nanorods sensitized with three different biomass-derived carbon quantum dots (CQDs) were synthesized, characterized, and used for the first time to build solid-state nanostructured solar cells. The performance of the devices was dependent on the
Eva Woltmann et al.
Analytical and bioanalytical chemistry, 406(25), 6347-6362 (2014-08-12)
High production output of solid pharmaceutical formulations requires fast methods to ensure their quality. Likewise, fast analytical procedures are required in forensic sciences, for example at customs, to substantiate an initial suspicion. We here present the design and the optimization
Jie Ma et al.
Talanta, 143, 205-211 (2015-06-17)
Hollow cross-linked fluorescent carbon nitride nanoparticles (CNNPs) were fabricated via a facile one-pot solvothermal process. The obtained CNNPs were characterized by multiple analytical techniques including transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), solid-state nuclear magnetic resonance
Miaomiao Zhang et al.
International journal of nanomedicine, 10, 6943-6953 (2015-11-27)
X-ray computed tomography (CT) is the most commonly used imaging technique for noninvasive diagnosis of disease. In order to improve tissue specificity and prevent adverse effects, we report the design and synthesis of iodine-doped carbon dots (I-doped CDs) as efficient
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