1597005

Quinine sulfate

United States Pharmacopeia (USP) Reference Standard

• Sinónimos: Quinine hemisulfate salt monohydrate
• Fórmula empírica (notación de Hill): C₂₀H₂₄N₂O₂ · 0.5H₂O₄S · H₂O
• Número de CAS: 207671-44-1
• Peso molecular: 391.47
• Beilstein: 6113937
• Número MDL: MFCD00150790
• Código UNSPSC: 41116107
• ID de la sustancia en PubChem: 329751013
• NACRES: NA.24

Propiedades

• grado: pharmaceutical primary standard
• familia API: quinine
• mol peso: monograph mol wt. 782.94
• fabricante / nombre comercial: USP
• mp: ~225 °C (dec.) (lit.)
• aplicaciones: pharmaceutical (small molecule)
• Formato: neat
• cadena SMILES: O.O.OS(O)(=O)=O.COc1ccc2nccc([C@@H](O)C3CC4CCN3C[C@@H]4C=C)c2c1.COc5ccc6nccc([C@@H](O)C7CC8CCN7C[C@@H]8C=C)c6c5
• InChI: 1S/2C20H24N2O2.H2O4S.2H2O/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;;/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);2*1H2/t2*13-,14-,19-,20+;;;/m00.../s1
• Clave InChI: ZHNFLHYOFXQIOW-LPYZJUEESA-N

Descripción

Descripción general

(C₂₀H₂₄N₂O₂)₂ . H₂SO₄ . 2H₂O

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Quinine sulfate is the sulfate salt of quinine, an alkaloid, obtained from the bark of Cinchona species.

Aplicación

Quinine sulfate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Quinine Sulfate Capsules
• Quinine Sulfate Tablets

Acciones bioquímicas o fisiológicas

Potassium channel blocker. Antimalarial

Potassium channel blocker. Antimalarial, anticholinergic, antihypertensive, and hypoglycemic agent; alkaloid originally isolated from the Cinchona family of South American trees. Inhibits mitochondrial ATP-regulated potassium channel. Used to study the metabolism of biocrystalized heme, hemozoin, in malarial parasites and to study the toxicity of heme (FP)-complexes.

Nota de análisis

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Otras notas

Sales restrictions may apply.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H315,H319,H335
• Consejos de prudencia: P305 + P351 + P338
• Clasificaciones de peligro: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órganos de actuación: Respiratory system
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable