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L0750500

Lorazepam

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

(±)-Lorazepam, 7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one

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About This Item

Fórmula empírica (notación de Hill):
C15H10Cl2N2O2
Número de CAS:
846-49-1
Peso molecular:
321.16
Número MDL:
MFCD00063406
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
329817375
NACRES:
NA.24

grado

pharmaceutical primary standard

familia API

lorazepam

fabricante / nombre comercial

EDQM

control farmacológico

regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)

aplicaciones

pharmaceutical (small molecule)

Formato

neat

cadena SMILES

OC1N=C(c2ccccc2Cl)c3cc(Cl)ccc3NC1=O

InChI

1S/C15H10Cl2N2O2/c16-8-5-6-12-10(7-8)13(19-15(21)14(20)18-12)9-3-1-2-4-11(9)17/h1-7,15,21H,(H,18,20)

Clave InChI

DIWRORZWFLOCLC-UHFFFAOYSA-N

Información sobre el gen

human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879)

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Descripción general

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

Lorazepam EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Envase

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Otras notas

Sales restrictions may apply.

Producto relacionado

Referencia del producto
Descripción
Precios

1370327

Lorazepam Related Compound A, United States Pharmacopeia (USP) Reference Standard

Y0000576

Lorazepam for system suitability, European Pharmacopoeia (EP) Reference Standard

1370305

Lorazepam, United States Pharmacopeia (USP) Reference Standard

1370338

Lorazepam Related Compound B, United States Pharmacopeia (USP) Reference Standard

Y0000718

Lorazepam impurity D, European Pharmacopoeia (EP) Reference Standard

1370349

Lorazepam Related Compound C, United States Pharmacopeia (USP) Reference Standard

1370350

Lorazepam Related Compound D, United States Pharmacopeia (USP) Reference Standard

1370360

Lorazepam Related Compound E, United States Pharmacopeia (USP) Reference Standard

BP434

Lorazepam, British Pharmacopoeia (BP) Reference Standard

BP376

6-Chloro-4-(2-chlorophenyl)quinazoline-2-carboxaldehyde, British Pharmacopoeia (BP) Reference Standard

Pictogramas

Health hazard
GHS08

Palabra de señalización

Warning

Frases de peligro

H361d

Clasificaciones de peligro

Repr. 2

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

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The choice of the optimal benzodiazepine to treat prehospital status epilepticus is unclear. Lorazepam is preferred in the emergency department, but concerns about nonrefrigerated storage limits emergency medical services (EMS) use. Midazolam is increasingly popular, but its heat stability is
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Olugbenga A Akingbola et al.
American journal of critical care : an official publication, American Association of Critical-Care Nurses, 21(6), 456-459 (2012-11-03)
A 6-year-old girl displayed symptoms of serotonin syndrome after accidental ingestion of Vyvanse (lisdexamfetamine dimesylate). Dexmedetomidine was administered because of persistent neuromuscular hyperactivity and severe agitation despite initial therapy with benzodiazepines. Some children show a paradoxical reaction to benzodiazepines, and
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Journal of psychiatric practice, 19(1), 15-28 (2013-01-22)
Delirious mania is a severe but under-recognized neuropsychiatric syndrome characterized by the rapid onset of delirium, mania, and psychosis, not associated with a prior toxicity, physical illness, or mental disorder. Catatonia is often a prominent feature of the syndrome. While
G Marti et al.
Human & experimental toxicology, 32(3), 332-334 (2012-11-24)
Ritalin® (methylphenidate) is an amphetamine-like prescription stimulant commonly used in the treatment of attention deficit hyperactivity disorder in children and adults. Recently, the recreational use of Ritalin has increased, particularly among young adults. Well-known symptoms of intoxication include signs of
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