530006

Prion Protein, His•Tag^®, Human, Recombinant, E. coli

• Sinónimos: rhPrP ^c, rhPrP^c
• UNSPSC Code: 12352202
• NACRES: NA.32

Propiedades

• assay: ≥95% (SDS-PAGE)
• Quality Level: 100
• form: liquid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; avoid repeated freeze/thaw cycles
• shipped in: wet ice
• storage temp.: −20°C

Descripción

General description

Recombinant, human prion protein (amino acids 23-231) fused to a His•Tag sequence and expressed in E. coli. Prion diseases or transmissible spongiform encephalopathies are neurodegenerative diseases that affect both humans and animals. All prion diseases share the same molecular pathogenic mechanism that involves conversion of normal cellular prion protein (PrPc) into a form that is insoluble in non-ionic detergent and partially resistant to proteases (PrPsc). Useful as an antigen standard in immunochemical detection of Creutzfeldt-Jakob Disease (CJD).

Recombinant, human prion protein (amino acids 23-231) fused to a His•Tag sequence and expressed in E. coli. Useful as an antigen standard in immunochemical detection of Creutzfeldt-Jakob Disease (CJD).

Warning

Toxicity: Standard Handling (A)

Physical form

In 10 mM sodium acetate, pH 4.0.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C).

Other Notes

Calzolai, L., and Zahn, R. 2003. J. Biol. Chem.278, 35592.
Prusiner, S.B. 1998. Proc. Natl. Acad. Sci. USA95, 13363.
Swietnicki, W., et al. 1997. J. Biol. Chem.272, 27517.
Pan, K.M., et al. 1993. Proc. Natl. Acad. Sci. USA90, 10962.
Basler, K., et al. 1986. Cell46, 417.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

HIS TAG is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable