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Principaux documents

SAB4504207

Sigma-Aldrich

Anti-phospho-Smad2 (pSer250) antibody produced in rabbit

affinity isolated antibody

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 52 kDa

Espèces réactives

mouse, human, rat

Concentration

~1 mg/mL

Technique(s)

ELISA: 1:10000
western blot: 1:500-1:1000

Numéro d'accès NCBI

Q15796

Numéro d'accès UniProt

Q15796

Application(s)

research pathology

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

phosphorylation (pSer250)

Informations sur le gène

human ... SMAD2(4087)

Catégories apparentées

Description générale

SMAD2 (SMAD family member 2) is also called as MADR2 (substrate of the TGFβ receptor). It is located on human chromosome 18q21. This gene belongs to the mothers against Dpp (MAD) related family of proteins. SMAD2 has two highly conserved amino and carboxyl-terminal domains (MH1 and MH2 domains) but has no known structural motifs.

Immunogène

The antiserum was produced against synthesized peptide derived from human Smad2 around the phosphorylation site of Ser250.

Immunogen Range: 216-265

Application

Anti-phospho-Smad2 (pSer250) antibody has been used in immunoblotting.

Actions biochimiques/physiologiques

SMAD2 (SMAD family member 2) plays an important role in TGF-β(transforming growth factor β)/activin signaling pathways. Mutations in SMAD2 (SMAD family member 2) results in arterial aneurysms and dissections. Upregulation of Smad2 blocks the multiplication of gingival epithelial cells. Smad2 positively and negatively controls TGFβ-dependent transcription with the help of forkhead DNA-binding protein FAST2.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Frequency of Smad Gene Mutations in Human Cancers'
Riggins G J, et al.
Cancer Research (1997)
Smad2 and Smad3 Positively and Negatively Regulate TGF?-Dependent Transcription through the Forkhead DNA-Binding Protein FAST2
Labbe E, et al.
Molecular Cell, 2, 109-120 (1998)
SMAD2 Mutations Are Associated with Arterial Aneurysms and Dissections
Micha D, et al.
Human Mutation, 36(12), 1145-1149 (2015)
Cytoplasmic PML promotes TGF-?-associated epithelial-mesenchymal transition and invasion in prostate cancer
Buczek ME, et al.
Oncogene, 35(26), 3465-3475 (2016)
M E Buczek et al.
Oncogene, 35(26), 3465-3475 (2015-11-10)
Epithelial-mesenchymal transition (EMT) is a key event that is involved in the invasion and dissemination of cancer cells. Although typically considered as having tumour-suppressive properties, transforming growth factor (TGF)-β signalling is altered during cancer and has been associated with the
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