P0069

PRIMA-1

≥98% (HPLC), solid

• Synonyme(s) : 2,2-Bishydroxymethyl-1-aza-bicyclo[2.2.2]octan-3-one
• Formule empirique (notation de Hill): C₉H₁₅NO₃
• Numéro CAS: 5608-24-2
• Poids moléculaire : 185.22
• Numéro MDL: MFCD04974196
• Code UNSPSC : 12352200
• ID de substance PubChem : 329820004
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥98% (HPLC)
• Forme: solid
• Couleur: white to off-white
• Solubilité: H₂O: >10 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: OCC1(CO)N2CC[C@@H](CC2)C1=O
• InChI: 1S/C9H15NO3/c11-5-9(6-12)8(13)7-1-3-10(9)4-2-7/h7,11-12H,1-6H2
• Clé InChI: RFBVBRVVOPAAFS-UHFFFAOYSA-N

Description

Description générale

P53-dependent reactivation and induction of massive apoptosis (PRIMA-1) is a low molecular weight compound and has a role in cancer therapy. PRIMA-1 stimulates cytotoxic effects in human cancer cells. It induces eryptosis.

Actions biochimiques/physiologiques

PRIMA-1 is a selective re-activator of mutant p53 activity in tumor cells, and an inducer of apoptosis and inhibitor of growth of human tumors with mutant p53. Mutations in the tumor suppressor p53 take place in >50% tumor cells. PRIMA-1 selectively restores sequence-specific DNA binding and transactivational activity to mutant p53 proteins at μM concentrations. PRIMA-1 works as a re-activator of the apoptotic function of mutant p53 via conformational modulation of function-specific epitopes.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07
• Mention d'avertissement: Danger
• Mentions de danger: H302,H334
• Conseils de prudence: P301 + P312 + P330
• Classification des risques: Acute Tox. 4 Oral - Resp. Sens. 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Faceshields, Gloves