The biological activity of product No. M8699, (R)-MG132 was measured using J558L multiple myeloma cells and EMT6 breast cancer cells.
M8699
(R)-MG132
(R)-MG132
Synonyme(s) :
Z-L-Leu-D-Leu-L-Leu-al
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About This Item
Formule empirique (notation de Hill):
C26H41N3O5
Numéro CAS:
Poids moléculaire :
475.62
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.32
Le tarif et la disponibilité ne sont pas disponibles actuellement.
Produits recommandés
Essai
≥98%
Niveau de qualité
Solubilité
DMSO or DMF: 25 mg/mL
Température de stockage
−20°C
Chaîne SMILES
CC(C)C[C@@H](C(N[C@H](C(N[C@H](C=O)CC(C)C)=O)CC(C)C)=O)NC(OCC1=CC=CC=C1)=O
InChI
1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1
Clé InChI
TZYWCYJVHRLUCT-VABKMULXSA-N
Application
Actions biochimiques/physiologiques
MG132 (carbobenzoxy-Leu-Leu-leucinal) is a tri-peptide aldehyde. It possesses antitumor activity and boosts cytostatic/cytotoxic effects of chemo- and radiotherapy.[5] (R)-MG132 is a potent, membrane-permeable proteasome inhibitor. It can inhibit proteasome activity in lysates of J558L multiple myeloma cells and EMT6 breast cancer cells. The (R)-MG132 stereoisomer is a more effective inhibitor of chymotrypsin-like (ChTL), trypsin-like (TL), and peptidylglutamyl peptide hydrolyzing proteasome (PGPH) activities than the (S)-MG132.[5]
Forme physique
crystalline solid or supercooled liquid
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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Which cells are utilized to assess the bioactivity of Product No. M8699, also known as (R)-MG132?
1 answer-
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What is the molarity of a solution with a concentration of 25 mg/ml in DMSO?
1 answer-
The molarity of a 25 mg/ml solution is 0.052 M, which is equivalent to 52 mM. This calculation is based on a substance with a molar mass of 475.62 g/mol, where a 1 M solution is prepared by dissolving 475.62 g in 1 liter.
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